73404-23-6

Upstream product

• 32161-30-1 (S)-3,4-dimethoxyphenylalanine 
• 501-53-1 benzyl chloroformate 
• 59-92-7 levodopa 

Downstream Products

• 889651-14-3 [(S)-1-(3,4-Dimethoxy-benzyl)-2-oxo-2-pyrrolidin-1-yl-ethyl]-carbamic acid benzyl ester 
• 1173933-75-9 [(1S,3S)-6,7-dimethoxy-1-phenyl-1,2,3,4-tetrahydroisoquinolin-3-yl]methanol 
• 128595-72-2 (S)-methyl 2-(benzyloxycarbonylamino)-3-(3,4-dimethoxyphenyl)propanoate 
• 78083-80-4 (S)-2-amino-3-(3,4-dimethoxyphenyl)propionic acid methyl ester 
• 161156-54-3 (-)-N-benzyloxycarbonyl-2-nitro-3,4-dihydroxyphenylalanine methyl ester 
• 889651-15-4 (S)-2-Amino-3-(3,4-dimethoxy-phenyl)-1-pyrrolidin-1-yl-propan-1-one 

Relevant academic research and scientific papers

Anticancer activity of ruthenium(II) arene complexes bearing 1,2,3,4-tetrahydroisoquinoline amino alcohol ligands

Ruthenium complexes offer potential reduced toxicity compared to current platinum anticancer drugs. 1,2,3,4-tetrahydrisoquinoline amino alcohol ligands were synthesised, characterised and coordinated to an organometallic Ru(II) centre. These complexes were evaluated for activity against the cancer cell lines MCF-7, A549 and MDA-MB-231 as well as for toxicity in the normal cell line MDBK. They were observed to be moderately active against only the MCF-7 cells with the best IC50 value of 34 μM for the cis-dia-stereomeric complex C4. They also displayed excellent selectivity by being relatively inactive against the normal MDBK cell line with SI values ranging from 2.3 to 7.4.

Design of a small-molecule catalyst using intramolecular cation-π interactions for enantioselective Diels-Alder and Mukaiyama-Michael reactions: L-DOPA-derived monopeptide·Cu(II) complex

We have designed a small-molecule artificial metalloenzyme that is prepared in situ from Cu(OTf)2 or Cu(NTf2)2 (1.0 equiv) and L-DOPA-derived monopeptide (1.1 equiv). This catalyst (2-10 mol %) is highly effective for the enantioselective Diels-Alder (DA) and Mukaiyama-Michael (MM) reactions with α,β-unsaturated 1-acyl-3,5-dimethylpyrazoles. The present results demonstrate that cation-π interactions may be available for controlling the conformation of sidearms of chiral ligands, and monopeptides are readily tunable ligands that include only one chiral center.