1286189-16-9 Usage
Uses
Used in Pharmaceutical and Medicinal Chemistry:
(1R)-6,6'-bis[3,5-bis(trifluoroMethyl)phenyl]-2,2',3,3'-tetrahydro-1,1'-Spirobi[1H-indene]-7,7'-diol is used as a potential candidate in drug design and development due to its unique structure and functional groups. It may contribute to the discovery of new therapeutic agents with novel mechanisms of action.
Used in Synthetic Chemistry and Organic Synthesis Studies:
(1R)-6,6'-bis[3,5-bis(trifluoroMethyl)phenyl]-2,2',3,3'-tetrahydro-1,1'-Spirobi[1H-indene]-7,7'-diol is used as a valuable target in synthetic chemistry and organic synthesis studies. Its unique structure and functional groups provide opportunities for the development of new synthetic methods and the exploration of its reactivity and properties in various chemical reactions.
Check Digit Verification of cas no
The CAS Registry Mumber 1286189-16-9 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,8,6,1,8 and 9 respectively; the second part has 2 digits, 1 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1286189-16:
(9*1)+(8*2)+(7*8)+(6*6)+(5*1)+(4*8)+(3*9)+(2*1)+(1*6)=189
189 % 10 = 9
So 1286189-16-9 is a valid CAS Registry Number.
1286189-16-9Relevant academic research and scientific papers
Phosphoramidite gold(I)-catalyzed diastereo- and enantioselective synthesis of 3,4-substituted pyrrolidines
Gonzalez, Ana Z.,Benitez, Diego,Tkatchouk, Ekaterina,Goddard, William A.,Toste, F. Dean
, p. 5500 - 5507 (2011/06/10)
In this article the utility of phosphoramidite ligands in enantioselective AuI catalysis was explored in the development of highly diastereo- and enantioselective AuI-catalyzed cycloadditions of allenenes. A AuI-catalyzed synthesis of 3,4-disubstituted pyrrolidines and γ-lactams is described. This reaction proceeds through the enantioselective AuI-catalyzed cyclization of allenenes to form a carbocationic intermediate that is trapped by an exogenous nucleophile, resulting in the highly diastereoselective construction of three contiguous stereogenic centers. A computational study (DFT) was also performed to gain some insight into the underlying mechanisms of these cycloadditions. The utility of this new methodology was demonstrated through the formal synthesis of (-)-isocynometrine.(Figure Presented)
