1286202-13-8Relevant academic research and scientific papers
Synthesis of pyrazoles from 1,3-diols via hydrogen transfer catalysis
Schmitt, Daniel C.,Taylor, Alexandria P.,Flick, Andrew C.,Kyne, Robert E.
, p. 1405 - 1408 (2015)
1,3-Diols engage in ruthenium-catalyzed hydrogen transfer in the presence of alkyl hydrazines to provide 1,4-disubstituted pyrazoles. Regioselective synthesis of unsymmetrical pyrazoles from β-hydroxy ketones is also described.
Cu-catalysed pyrazole synthesis in continuous flow
Comas-Barceló, Júlia,Blanco-Ania, Daniel,Van Den Broek, Sebastiaan A. M. W.,Nieuwland, Pieter J.,Harrity, Joseph P. A.,Rutjes, Floris P. J. T.
, p. 4718 - 4723 (2016)
The synthesis of 1,4-disubstituted pyrazoles via the cycloaddition reaction of sydnones and terminal alkynes has been achieved employing silica-supported copper catalysts. Furthermore, this methodology has been successfully implemented in continuous flow
One-pot synthesis of 1,4-disubstituted pyrazoles from arylglycines via copper-catalyzed sydnone-alkyne cycloaddition reaction
Specklin, Simon,Decuypere, Elodie,Plougastel, Lucie,Aliani, Soifia,Taran, Frédéric
, p. 7772 - 7777 (2014/10/15)
A robust method for constructing 1,4-pyrazoles from arylglycines was developed using the copper-catalyzed sydnone-alkyne cycloaddition reaction. The procedure offers a straightforward and general route to the pyrazole heterocycle through a three-step one-pot procedure.
Discovery of chemoselective and biocompatible reactions using a high-throughput immunoassay screening
Kolodych, Sergii,Rasolofonjatovo, Evelia,Chaumontet, Manon,Nevers, Marie-Claire,Creminon, Christophe,Taran, Frederic
, p. 12056 - 12060 (2013/12/04)
An immunoassay-based method was used to screen numerous combinations of dipoles and dipolarophiles for their ability to undergo chemoselective and biocompatible [3+2] cycloaddition reactions. The approach fulfills most of the requirements of the click concept and led to the discovery of a copper-catalyzed reaction that generates pyrazoles from sydnone and alkyne reagents. Copyright
Regioselectivity studies of sydnone cycloaddition reactions of azine-substituted alkynes
Foster, Robert S.,Jakobi, Harald,Harrity, Joseph P.A.
scheme or table, p. 1506 - 1508 (2011/05/16)
The synthesis of azine-substituted pyrazoles by a sydnone cycloaddition strategy is described. Incorporation of a 3-pyridyl moiety at the sydnone N-atom has little effect on either reactivity or regioselectivity, however, 2-ethynyl-pyridine and -pyrimidin
