1286232-24-3

Basic information

• Product Name: 3-(3-chloro-5-hydroxyphenyl)-N-(2-(diethylamino)ethyl)-4-(pyridin-4-yl)-1H-pyrazole-1-carboxamide
• Synonyms: 3-(3-chloro-5-hydroxyphenyl)-N-(2-(diethylamino)ethyl)-4-(pyridin-4-yl)-1H-pyrazole-1-carboxamide
• CAS NO: 1286232-24-3
• Molecular Weight: 413.907
• Mol File: 1286232-24-3.mol

Chemical Properties

• CAS DataBase Reference: 3-(3-chloro-5-hydroxyphenyl)-N-(2-(diethylamino)ethyl)-4-(pyridin-4-yl)-1H-pyrazole-1-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(3-chloro-5-hydroxyphenyl)-N-(2-(diethylamino)ethyl)-4-(pyridin-4-yl)-1H-pyrazole-1-carboxamide(1286232-24-3)
• EPA Substance Registry System: 3-(3-chloro-5-hydroxyphenyl)-N-(2-(diethylamino)ethyl)-4-(pyridin-4-yl)-1H-pyrazole-1-carboxamide(1286232-24-3)

Safety Data

• Hazardous Substances Data: 1286232-24-3(Hazardous Substances Data)

Upstream product

• 96826-41-4 methyl 3-chloro-5-methoxybenzoate 
• 82477-67-6 3-chloro-5-methoxy-benzoic acid 
• 51-36-5 3,5-dichlorobenzoic acid 
• 950525-41-4 1-(3-chloro-5-methoxyphenyl)-2-(pyridin-4-yl)ethanone 
• 1286232-09-4 3-(3-chloro-5-methoxyphenyl)-N-(2-(diethylamino)ethyl)-4-(pyridin-4-yl)-1H-pyrazole-1-carboxamide 

Relevant articles and documents

Antiproliferative diarylpyrazole derivatives as dual inhibitors of the ERK pathway and COX-2

A series of 3,4-diarylpyrazole-1-carboxamide derivatives was designed and synthesized. A selected group of the target compounds was tested for in vitro antiproliferative activities over a panel of 60 cancer cell lines at the National Cancer Institute (NCI, Bethesda, MD, USA) at a single-dose concentration of 10 μm, and the four most active compounds 9a, 9l, 9n, and 10o were further tested in a five-dose testing mode to determine their IC50 values over the 60 cell lines. In addition, a selected group of target compounds were tested for inhibitory effect over cyclooxygenase isozymes. Compounds 9a, 9l, 9n, and 10o were also tested for MEK and ERK kinase inhibitory activity using Western blot assay. Compound 10o was selective toward melanoma cell line subpanel, and its antiproliferative activity may be attributed to selective cyclooxygenase-2 inhibition and ERK pathway inhibition.

Synthesis of 1H-Pyrazole-1-carboxamide derivatives and their antiproliferative activity against melanoma cell line

Synthesis of a new series of 1H-pyrazole-1-carboxamide derivatives is described. Their antiproliferative activity against A375 human melanoma cell line was tested and the effect of substituents on the diarylpyrazole scaffold was investigated. The pharmacological results indicated that most of the newly synthesized compounds showed moderate activity against A375, compared with sorafenib. Among all of these derivatives, compound IIe which has N-methylpiperazinyl and phenolic moieties showed the most potent antiproliferative activity against A375 human melanoma cell line.