1286238-75-2Relevant academic research and scientific papers
Synthesis, antiproliferative and apoptotic activities of N-(6(4)-indazolyl)-benzenesulfonamide derivatives as potential anticancer agents
Abbassi, Najat,Chicha, Hakima,Rakib, El Mostapha,Hannioui, Abdellah,Alaoui, Mdaghri,Hajjaji, Abdelouahed,Geffken, Detlef,Aiello, Cinzia,Gangemi, Rosaria,Rosano, Camillo,Viale, Maurizio
, p. 240 - 249 (2013/01/15)
Recently, it has been reported that compounds bearing a sulfonamide moiety possess many types of biological activities, including anticancer activity. The present work reports the synthesis and antiproliferative evaluation of some N-(6(4)-indazolyl)benzenesulfonamides and 7-ethoxy-N-(6(4)-indazolyl) benzenesulfonamides. All compounds were evaluated for their in vitro antiproliferative activity against three tumor cell lines: A2780 (human ovarian carcinoma) A549 (human lung adenocarcinoma) and P388 (murine leukemia). The results indicated that sulfonamides 2c, 3c, 6d, 8, 13, 3b and 16 were endowed with a pharmacologically interesting antiproliferative activity with compounds 2c and 3c showing the lower IC50 (from 0.50 ± 0.09 to 1.83 ± 0.52 μM and from 0.58 ± 0.17 to 5.83 ± 1.83 μM, respectively). Moreover, these indazoles were able to trigger apoptosis through the upregulation of the typical apoptosis markers p53 and bax. As regard to the hypothetic targets of these compounds, a preliminary docking analysis showed that all compounds seemed to interact with β-tubulin, in particular compound 3b that showed the lower Ki. The cytofluorimetric analysis of the cell cycle phases indicates that all compounds, when administered at their IC 75, caused a block in the G2/M phase of the cell cycle with the generation of subpopulations of cells with a number of chromosome >4n. When the IC50s were applied we observed a prevalent block in the G0/G1 phase except for compounds 16 and 8 where a partial G2/M block was present with a concomitant decrease of cells in the G0/G1 and S phases of the cell cycle. Altogether these results suggest a possible, but not exclusive, interaction with microtubules.
Studies on the reduction of the nitro group in 4-nitroindazoles by anhydrous SnCl2in different alcohols
Abbassi,Rakib,Bouissane,Hannioui,Khouili,El Malki,Benchidmi,Essassi
experimental part, p. 999 - 1005 (2011/04/23)
(Chemical Equation Presented) The synthesis of new 7-alkoxy-4-amino- protected indazole and 4-amino-protected indazole derivatives by the reduction of the nitro group of 4-nitroindazoles using anhydrous stannous chloride in different alcohols is described
