74209-17-9

Usage

Uses

Used in Medicinal Chemistry:
3-Bromo-4-Nitro (1H)Indazole is used as an organic intermediate for the synthesis of various compounds in medicinal chemistry. Its unique structural properties allow it to engage in a wide range of chemical reactions, making it a valuable component in the development of new pharmaceuticals.
Used in Drug Discovery:
In the field of drug discovery, 3-Bromo-4-Nitro (1H)Indazole serves as a crucial intermediate for the creation of potential drug candidates. Its ability to participate in diverse chemical reactions contributes to the exploration of novel therapeutic agents and the advancement of medical treatments.
Used in Research and Development Activities:
3-Bromo-4-Nitro (1H)Indazole is utilized as a key component in research and development activities, particularly in the pharmaceutical industry. Its presence in a solid state and its reactivity in chemical reactions make it an essential tool for scientists and researchers working on the design and synthesis of new chemical entities with potential therapeutic applications.

InChI:InChI=1/C7H4BrN3O2/c8-7-6-4(9-10-7)2-1-3-5(6)11(12)13/h1-3H,(H,9,10)

Upstream product

• 2942-40-7 nitro-4 indazole 
• 603-83-8 3-nitro-o-tolylamine 

Downstream Products

• 1286238-78-5 N-(3-bromo-1H-indazol-4-yl)-4-methyl-benzenesulfonamide 
• 1286238-75-2 N-(3-bromo-7-ethoxy-1H-indazol-4-yl)-4-methyl-benzenesulfonamide 
• 1313408-93-3 3-bromo-1-((6-methylpyridin-2-yl)methyl)-4-nitro-1H-indazole 
• 1313409-07-2 1-benzyl-3-bromo-4-nitro-1H-indazole 
• 885521-25-5 4-amino-3-bromoindazole 
• 1383473-11-7 3-bromo-1-((6-isopropylpyridin-2-yl)methyl)-4-nitro-1H-indazole 
• 1339955-94-0 4-[4-nitro-1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-3-yl]piperazin-1-carboxylic acid benzyl ester 

Relevant academic research and scientific papers

Synthesis and evaluation of thieno[3,2-d]pyrimidine derivatives as novel FMS inhibitors

Colony stimulating factor-1 receptor (CSF-1R or FMS) and it ligand, CSF-1, signaling regulates the differentiation and function of tumor-associated macrophages (TAMs) that play an important role in tumor progression. Derivatives of thieno[3,2-d]pyrimidine were synthesized and evaluated as kinase inhibitors of FMS. The most representative compound 21 showed strong activity (IC50 = 2 nM) against FMS kinase and served as candidate for proof of concept. Anti-tumor activity alone and/or in combination with paclitaxel was examined via a tumor cell growth inhibition assay and via an in vitro tumor invasion assay using human breast adenocarcinoma cells.

FUSED PYRIMIDINE DERIVATIVES HAVING INHIBITORY ACTIVITY ON FMS KINASES

Disclosed are a fused pyrimidine derivative of formula (I), and a pharmaceutically acceptable salt, stereoisomer, hydrate and solvate thereof, which have an excellent inhibitory activity on FMS kinases, and a pharmaceutical composition comprising the same is effective in preventing or treating diseases caused by abnormal activation of FMS kinases such as immunologic diseases, metabolic diseases, inflammatory diseases, cancers and tumors.

SUBSTITUTED N-(1H-INDAZOL-4-YL)IMIDAZO[1,2-a]PYRIDINE-3-CARBOXAMIDE COMPOUNDS AS TYPE III RECEPTOR TYROSINE KINASE INHIBITORS

Compounds of Formula I: and pharmaceutically acceptable salts thereof in which R1, R2, R3, R4, R5 and R6 have the meanings given in the specification, are inhibitors of cFMS and are useful in the treatment of fibrosis, bone-related diseases, cancer, autoimmune disorders, inflammatory diseases, cardiovascular diseases, pain and burns in a mammal

Studies on the reduction of the nitro group in 4-nitroindazoles by anhydrous SnCl2in different alcohols

(Chemical Equation Presented) The synthesis of new 7-alkoxy-4-amino- protected indazole and 4-amino-protected indazole derivatives by the reduction of the nitro group of 4-nitroindazoles using anhydrous stannous chloride in different alcohols is described

Direct access to 3-aminoindazoles by Buchwald-Hartwig C-N coupling reaction

An efficient synthesis of various N-substituted 3-aminoindazoles using Buchwald-Hartwig C-N coupling reaction is described. Several parameters were varied, including the nature of the halogen atom and the protecting group of the starting materials, as well as the effects of the catalyst system, base, solvent, and reaction time. The efficiency of microwave versus conventional heating was also compared to test the outcome of the reaction. Thus, by applying this recent knowledge about metal-catalyzed aminations, an alternative for the direct synthesis of primary 3-aminoindazoles has been provided. Georg Thieme Verlag Stuttgart. New York.

SUBSTITUTED N-(1H-INDAZOL-4-YL)IMIDAZO[1, 2-A]PYRIDINE-3- CARBOXAMIDE COMPOUNDS AS CFMS INHIBITORS

Compounds of Formula (I): and pharmaceutically acceptable salts thereof in which R1, R2, R3, R4 and R5 have the meanings given in the specification, are inhibitors of cFMS and are useful in the treatment of bone-related diseases, cancer, autoimmune disorders, inflammatory diseases, cardiovascular diseases and pain.