1286261-80-0Relevant academic research and scientific papers
Nickel-Mediated Cross-Coupling of Boronic Acids and Phthalimides for the Synthesis of Ortho-Substituted Benzamides
Ahlgrim, Grace C.,Deglopper, Kimberly S.,Dennis, Joseph M.,Heyboer, Ethan M.,Johnson, Jeffrey B.,Johnson, Rebecca L.,Kwiatkowski, Megan R.,Pankratz, Trey C.,Yoder, Mason C.
, p. 3757 - 3765 (2020)
The decarbonylative coupling of phthalimides with aryl boronic acids provides ready access to a broad range of ortho-substituted benzamides. This nickel-mediated methodology extends reactivity from previously described air-sensitive diorganozinc reagents of limited availability to easily handled and widely commercially available boronic acids. The decarbonylative coupling is tolerant of a broad range of functional groups and demonstrates little sensitivity to steric factors on either of the coupling partners.
Nickel-mediated decarbonylative cross-coupling of phthalimides with in situ generated diorganozinc reagents
Havlik, Sarah E.,Simmons, Jessica M.,Winton, Valerie J.,Johnson, Jeffrey B.
experimental part, p. 3588 - 3593 (2011/06/26)
The nickel-mediated cross-coupling of phthalimides with diorganozinc reagents proceeds via a decarbonylative process to produce ortho-substituted benzamides in high yields. In addition to tolerating diverse phthalimide functionality, including alkyl, aryl
