128641-38-3

Basic information

• Product Name: 6-(3-chlorophenyl)-4-(1,1-dimethyl-2-hydroxyethylamino)-2-methylthiopyrimidine-5-carbonitrile
• CAS NO: 128641-38-3
• Molecular Weight: 348.856
• Mol File: 128641-38-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 6-(3-chlorophenyl)-4-(1,1-dimethyl-2-hydroxyethylamino)-2-methylthiopyrimidine-5-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 6-(3-chlorophenyl)-4-(1,1-dimethyl-2-hydroxyethylamino)-2-methylthiopyrimidine-5-carbonitrile(128641-38-3)
• EPA Substance Registry System: 6-(3-chlorophenyl)-4-(1,1-dimethyl-2-hydroxyethylamino)-2-methylthiopyrimidine-5-carbonitrile(128641-38-3)

Safety Data

• Hazardous Substances Data: 128641-38-3(Hazardous Substances Data)

Upstream product

• 128641-01-0 4-(3-chlorophenyl)-2-(methylthio)-6-oxo-1,6-dihydropyrimidine-5-carbonitrile 
• 587-04-2 m-Chlorobenzaldehyde 
• 128640-94-8 6-(3-chlorophenyl)-4-oxo-2-sulfanylidene-1,2,3,4-tetrahydropyrimidine-5-carbonitrile 
• 124-68-5 2-Amino-2-methyl-1-propanol 
• 128641-31-6 4-chloro-6-(3-chlorophenyl)-2-methylthiopyrimidine-5-carbonitrile 

Relevant articles and documents

Chemotherapeutic Agents. XII - Synthesis of Pyrimidines and Fused Pyrimidines as Leishmanicides and Herbicides

Various bicyclic (2, 3) and tricyclic (4, 5) heterocycles were prepared by the reaction of 1a, c with dihaloalkanes and polynitrohalobenzene separately.Electrophilic substitution on 1a-c with different alkyl halides yielded mono and dialkyl pyrimidines (6-20).Nucleophilic substitution reactions on 18 and 21 with amine and hydrazine separately yielded 22-31, 21a, b and 41c.Reaction of 25a with ethyl ethoxymethylenecyanoacetate and chloroacetyl chloride separately provided bicyclic compounds 32 and 33.Condensation-cyclization of 25a with formic, acetic and nitrous acid separately yielded 34a, b and 35.Reaction of 26a with ethylthioglycolate and thiourea separately provided 36a and 39.The latter was alkylated with methyl iodide to 40.An attempt to cyclize 29a and 30a with thionyl chloride provided bicyclic compounds 37a, b and an uncyclic product 38.Some of the compounds were screened for leishmanicidal and herbicidal activities and a few of them exhibited significant activity.