1286538-20-2

Upstream product

• 4701-17-1 5-bromo-2-thiophencarboxaldehyde 
• 7311-63-9 5-bromothiophene-2-carboxylic acid 
• 31555-60-9 5-bromothiophene-2-carbonyl chloride 
• 5509-65-9 2,6-difluoroaniline 

Downstream Products

• 1361379-21-6 N-(2,6-difluorophenyl){5-[1-methyl-3-(5-methyl(1,2,4-oxadiazol-3-yl))pyrazol-5-yl](2-thienyl)}carboxamide 
• 1361379-40-9 N-(2,6-difluorophenyl){5-[3-(2-fluorophenyl)-1-methylpyrazol-5-yl](2-thienyl)}carboxamide 
• 1361379-68-1 N-(2,6-difluorophenyl)[5-(1-methyl-3-(2-thienyl)pyrazol-5-yl)(2-thienyl)]carboxamide 
• 1361379-61-4 N-(2,6-difluorophenyl)[5-(3-(2-furyl)-1-methylpyrazol-5-yl)(2-thienyl)]carboxamide 
• 1361379-54-5 (2,6-difluorophenyl)[5-(1-methyl-3-(1,3-thiazol-2-yl)pyrazol-5-yl)(2-thienyl)]carboxamide 
• 1361379-47-6 N-(2,6-difluorophenyl) [5-(1-methyl-3-phenylpyrazol-5-yl)(2-thienyl)]carboxamide 
• 1361379-08-9 [5-(5-chloro-2-methylbenzoxazol-6-yl)(2-thienyl)]-N-(2,6-difluorophenyl)carboxamide 
• 1361379-09-0 N-(2,6-difluorophenyl)[5-(6-methylbenzothiazol-5-yl)(2-thienyl)]carboxamide 
• 1361379-12-5 N-(2,6-difluorophenyl)[5-(5-chlorobenzothiazol-6-yl)(2-thienyl)]carboxamide 
• 1361379-20-5 [5-(2,5-dimethyl-2H-indazol-6-yl)(2-thienyl)]-N-(2,6-difluorophenyl)carboxamide 
• 1361379-15-8 N-(2,6-difluorophenyl)[5-(3,5-dimethylbenzo[d]isoxazol-6-yl)(2-thienyl)]carboxamide 
• 1373940-58-9 N-(2,6-difluorophenyl)-5-(trimethylstannyl)thiophene-2-carboxamide 
• 1373939-74-2 N-(2,6-difluorophenyl)-5-(2-methyl-5-(4-methyl-5-oxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)phenyl)thiophene-2-carboxamide 
• 1373939-60-6 N-(2,6-difluorophenyl)-5-(5-(5,5-dimethyl-4-oxo-4,5-dihydroisoxazol-3-yl)-2-methylphenyl)thiophene-2-carboxamide 

Relevant academic research and scientific papers

OXAZOLE AND ISOXAZOLE CRAC MODULATORS

The present invention relates to compounds of Formula (I) along with processes for their preparation that are useful for treating, preventing and/or managing the diseases, disorders, syndromes or conditions associated with the modulation of CRAC. The invention further relates to methods of treating, preventing managing and/or lessening the diseases, disorders, syndromes or conditions associated with the modulation of CRAC of Formula (I).

COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM

Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of SOC channel activity.