128657-65-8

Upstream product

• 126924-10-5 methyl 4,6-O-benzylidene-α-D-arabino-hexopyranosid-2-ulose 
• 97-30-3 methyl-alpha-D-glucopyranoside 
• 1125-88-8 benzaldehyde dimethyl acetal 
• 116561-28-5 methyl 2-amino-2-deoxy-4,6-O-(phenylmethylene)-α-D-mannopyranoside 
• 108-24-7 acetic anhydride 
• 116003-78-2 Methyl 2-azido-2-deoxy-4,6-O-(phenylmethylene)-α-D-mannopyranoside 
• 6082-04-8 methyl 2-acetylamido-2-deoxy-D-glucoside 
• 128583-64-2 methyl 4,6-O-benzylidene-α-D-arabino-2-hexulopyranoside O-methyloxime 
• 2880-96-8 methyl 2,3-anhydro-4,6-dioxabenzylidene-α-D-gulopyranose 

Downstream Products

• 6619-02-9 methyl-[2-acetylamino-O⁴,O⁶-((R)-benzylidene)-2-deoxy-α-D-altropyranoside] 

Relevant academic research and scientific papers

Synthesis of 1,2,3-triazolyl analog of Neisseria meningitidis A capsular polysaccharide

Towards constructing a stable, non-hydrolyzable linkage for Neisseria meningitidis type A (MenA) polysaccharide, the phosphate bridge of its (1→6)-linked 2-acetamido-2-deoxy-α-D-mannopyranosyl phosphate repeating unit was replaced by a triazolyl analog using Cu(I) catalyzed click reaction. The synthesis involved anomeric azidation of N-acetyl-D-mannosamine derivative from its acetate precursor using stoichiometric amount of FeCl3 and one-pot synthesis of precursors for di- and tri- triazolyl saccharides with an azidoethyl spacer at the reducing end for bioconjugation.

Tandem one-pot acetalation-acetylation for direct access to differentially protected thioglycosides and O-glycosides with p-toluenesulfonic acid

A new tandem one-pot acetalation-acetylation procedure is reported which streamlines routine protecting-group manipulation of carbohydrate molecules in production of differentially protected O- and thioglycosides. This new procedure eliminates the use of