128670-71-3Relevant academic research and scientific papers
Increasing 5-lipoxygenase inhibitory activities by oxidative conversion of o-methoxyphenols to catechols using a Cu2+ - ascorbic acid - O2 system
Aihara,Higuchi,Hirobe
, p. 842 - 844 (2007/10/02)
Several complicated o-methoxyphenols were oxidized with high selectivity to catechols by a Cu2+ - ascorbic acid - O2 system. In this way, the RBL-1 5-lipoxygenase inhibitory activities of o-methoxyphenols were greatly increased. [6]-Norgingerol (4), a novel compound derived from [6]-gingerol (3), shows promise as a lead compound for new drugs because of its high inhibitory potency (IC50 = 5.0 x 10-8 M).
