88776-68-5

Basic information

• Product Name: 7-Methoxy-2-methyl-4-phenyl-1,2,3,4-tetrahydro-isoquinolin-8-ol
• CAS NO: 88776-68-5
• Molecular Weight: 269.343
• Mol File: 88776-68-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 7-Methoxy-2-methyl-4-phenyl-1,2,3,4-tetrahydro-isoquinolin-8-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 7-Methoxy-2-methyl-4-phenyl-1,2,3,4-tetrahydro-isoquinolin-8-ol(88776-68-5)
• EPA Substance Registry System: 7-Methoxy-2-methyl-4-phenyl-1,2,3,4-tetrahydro-isoquinolin-8-ol(88776-68-5)

Safety Data

• Hazardous Substances Data: 88776-68-5(Hazardous Substances Data)

Upstream product

• 96-09-3 styrene oxide 
• 18087-80-4 o-vanillyl-methylamine 
• 88741-41-7 1-(2-(benzyloxy)-3-methoxyphenyl)-N-methylmethanamine 
• 88741-44-0 2-[(2-Benzyloxy-3-methoxy-benzyl)-methyl-amino]-1-phenyl-ethanol 
• 344864-13-7 2-{[(2-Hydroxy-2-phenyl-ethyl)-methyl-amino]-methyl}-6-methoxy-phenol 

Downstream Products

• 128670-71-3 2-Methyl-4-phenyl-1,2,3,4-tetrahydro-isoquinoline-7,8-diol 

Relevant articles and documents

Studies on tetrahydroisoquinolines. XXV. A synthesis of 4-aryl-1,2,3,4-tetrahydroisoquinolines; Total synthesis of (±)-cherylline

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A FACILE SYNTHESIS OF 4-ARYL-1,2,3,4-TETRAHYDROISOQUINOLINES: A TOTAL SYNTHESIS OF (+/-)-CHERYLLINE

Reaction of benzylamines (3a-d) and styrene oxide at 140 deg C gave quantitavely β-hydroxyphenethylamine (2a-d), acid treatment of which afforded 4-aryl-1,2,3,4-tetrahydroisoquinolines (8a-d) in high yields.On the other hand, the styrene oxide (10 or 15)