Cas 1286737-12-9,γ-azido-MTX

1286737-12-9

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Basic information

Product Name: γ-azido-MTX
Synonyms: γ-azido-MTX
CAS NO:1286737-12-9
Molecular Formula:
Molecular Weight: 536.553
EINECS: N/A
Product Categories: N/A

Chemical Properties

Melting Point: N/A
Boiling Point: N/A
Flash Point: N/A
Appearance: N/A
Density: N/A
Refractive Index: N/A
Storage Temp.: N/A
Solubility: N/A
CAS DataBase Reference: γ-azido-MTX(CAS DataBase Reference)
NIST Chemistry Reference: γ-azido-MTX(1286737-12-9)
EPA Substance Registry System: γ-azido-MTX(1286737-12-9)

Safety Data

Hazard Codes: N/A
Statements: N/A
Safety Statements: N/A
WGK Germany:
RTECS:
HazardClass: N/A
PackingGroup: N/A
Hazardous Substances Data: 1286737-12-9(Hazardous Substances Data)

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Check Digit Verification of cas no

The CAS Registry Mumber 1286737-12-9 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,8,6,7,3 and 7 respectively; the second part has 2 digits, 1 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 1286737-12:
(9*1)+(8*2)+(7*8)+(6*6)+(5*7)+(4*3)+(3*7)+(2*1)+(1*2)=189
189 % 10 = 9
So 1286737-12-9 is a valid CAS Registry Number.

1286737-12-9Upstream product

1286737-12-9Downstream Products

1286737-12-9Relevant academic research and scientific papers

Multifunctional small molecules

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, (2016/08/29)

The present invention relates to dendrimer synthesis. Specifically, the present invention relates to dendrimer compositions (e.g., scaffolds) capable of copper-free click conjugation for use in the synthesis of functionalized dendrimers, and methods of us

Design considerations for PAMAM dendrimer therapeutics

Goonewardena, Sascha N.,Kratz, Jeremy D.,Zong, Hong,Desai, Ankur M.,Tang, Shengzhuang,Emery, Sarah,Baker Jr., James R.,Huang, Baohua

, p. 2872 - 2875 (2013/06/27)

We have previously shown that methotrexate (MTX) conjugated to a cancer-specific poly amido amine (PAMAM) dendrimer has a higher therapeutic index than MTX alone. Unfortunately, these therapeutics have been difficult to advance because of the complicated

MULTIFUNCTIONAL SMALL MOLECULES

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Page/Page column 55; 56, (2013/06/27)

The facile synthesis of multifunctional PAMAM dendrimer conjugates through copper-free click chemistry

Huang, Baohua,Kukowska-Latallo, Jolanta F.,Tang, Shengzhuang,Zong, Hong,Johnson, Kali B.,Desai, Ankur,Gordon, Chris L.,Leroueil, Pascale R.,Baker Jr., James R.

, p. 3152 - 3156 (2012/06/18)

The facile conjugation of three azido modified functionalities, namely a therapeutic drug (methotrexate), a targeting moiety (folic acid), and an imaging agent (fluorescein) with a G5 PAMAM dendrimer scaffold with cyclooctyne molecules at the surface thro

Copper-free click conjugation of methotrexate to a PAMAM dendrimer platform

Huang, Baohua,Desai, Ankur,Zong, Hong,Tang, Shengzhuang,Leroueil, Pascale,Baker Jr., James R.

, p. 1411 - 1414 (2011/06/10)

The synthesis of a generation 5 (G5) poly(amidoamine) (PAMAM) dendrimer platform having cyclooctyne ligands that were subsequently be used for a copper-free Huisgen 1,3-dipolar cycloaddition (click reaction) with azido modified methotrexate is described.

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