1286776-16-6

Upstream product

• 364-83-0 2',4'-difluoroacetophenone 
• 196929-78-9 (R)-2-methylpropane-2-sulfinamide 

Downstream Products

• 1286776-17-7 C₂₂H₃₀F₂N₂O₄S₂ 
• 1286794-15-7 C₁₇H₁₇F₅N₂O₂S 
• 1286776-18-8 C₁₀H₁₄F₂N₂O₂S 
• 1286776-19-9 C₁₁H₁₅F₂N₃O₂S₂ 
• 1286770-24-8 C₁₁H₁₃F₂N₃O₂S 
• 1585971-01-2 C₁₈H₂₂F₂N₂O₃S 
• 1585971-02-3 C₂₃H₂₄F₂N₂O₃S 
• 1585971-03-4 C₂₃H₂₃ClF₂N₂O₃S 
• 1585971-04-5 C₂₀H₂₆F₂N₂O₃S 
• 1585971-05-6 C₂₁H₂₈F₂N₂O₃S 
• 1585971-06-7 C₁₉H₂₂F₄N₂O₃S 
• 1585971-11-4 C₂₅H₂₈F₂N₂O₃S 
• 1585971-12-5 C₂₄H₂₅F₃N₂O₃S 
• 1585971-14-7 C₂₅H₂₈F₂N₂O₄S 

Relevant academic research and scientific papers

ISOQUINOLINE COMPOUNDS, A PROCESS FOR THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

A compound of formula (I): wherein the substituents are as defined in the description. Medicinal products containing the same which are useful in treating or preventing pathologies which are the result of activation of the RhoA/ROCK pathway and phosphorylation of the myosin light chain.

Iminothiadiazine Dioxide Compounds as BACE Inhibitors, Compositions and Their Use

In its many embodiments, the present invention provides certain iminothiadiazine dioxide compounds, including compounds Formula (I): and include stereoisomers thereof, and pharmaceutically acceptable salts of said compounds stereoisomers, wherein each of R1, R2, R3, R4, R5, R9, ring A, ring B, m, n, p, -L1-, -L2-, and -L3- is selected independently and as defined herein. The novel iminothiadiazine dioxide compounds of the invention have surprisingly been found to exhibit properties which are expected to render them advantageous as BACE inhibitors and/or for the treatment and prevention of various pathologies related to β-amyloid (“Aβ”) production. Pharmaceutical compositions comprising one or more such compounds (alone and in combination with one or more other active agents), and methods for their preparation and use in treating pathologies associated with amyloid beta (Aβ) protein, including Alzheimer's disease, are also disclosed.

IMINOTHIADIAZINE DIOXIDE COMPOUNDS AS BACE INHIBITORS, COMPOSITIONS, AND THEIR USE

In its many embodiments, the present invention provides certain iminothiadiazine dioxide compounds, including compounds Formula (a) and include tautomers, solvates, prodrugs, esters, and deuterates thereof, and pharmaceutically acceptable salts of said compounds, tautomers, solvates, prodrugs, esters, and deuterates, wherein each of R1, R2, R3, R4, R5, R9, ring A, ring B, ring C, m, n, p, q, -L1-, -L2-,L3-, and L4 - is selected independently and as defined herein. The compounds of the invention have, surprisingly and advantageously, improved solution stability. Pharmaceutical compositions comprising one or more such compounds (alone and in combination with one or more other active agents), and methods for their preparation and use in treating pathologies associated with amyloid beta (Abeta) protein, including Alzheimers Disease, are also disclosed