128693-98-1Relevant academic research and scientific papers
Additions of aldehydes to metallated trans-1,3-dithiane-S,S-dioxide under conditions of kinetic and thermodynamic control
Aggarwal,Davies,Maddock,Mahon,Molloy
, p. 135 - 138 (1990)
The chiral acyl anion equivalent (1) can be metallated with n-BuLi/py and reacts with aldehydes to give adducts in high yield. At -78°C the reaction is under kinetic control whereas at 0°C equilibration occurs with PhCHO and t-BuCHO resulting in good yields of single diastereoisomers.
Anion Reactions of 1,3-Dithiane 1,3-Dioxide with Carbonyl Compounds: High Diastereoselectivity with Aromatic Aldehydes under Conditions of Equilibrium Control
Aggarwal, Varinder K.,Franklin, Richard,Maddock, John,Evans, Graham R.,Thomas, Abraham,et al.
, p. 2174 - 2182 (2007/10/02)
We have investigated the anion chemistry of trans-1,3-dithiane 1,3-dioxide (4) with aldehydes and ketones, and we have found that this reagent undergoes highly selective addition reactions with aromatic aldehydes but only when reactions are under equilibr
