1287205-76-8

Upstream product

• 118171-79-2 N-(t-butoxycarbonyl)-isoleucine aldehyde 
• 141321-52-0 N-(tert-butoxycarbonyl)-L-isoleucinol 
• 1287206-23-8 tert-butyl {(2S,3S)-1-[(4-bromophenyl)amino]-3-methylpentan-2-yl}carbamate 
• 1287205-75-7 (1R,2R)-2-(pyridin-2-yl)cyclopropanecarboxylic acid 
• 100-69-6 2-vinylpyridine 

Downstream Products

• 1287205-80-4 [(1S,2S)-1-({(4-bromophenyl)[(trans)-2-(5-fluoropyridin-2-yl)cyclopropanecarbonyl]amino}methyl)-2-methylbutyl]carbamic acid tert-butyl ester 

Relevant academic research and scientific papers

Synthesis, pharmacological characterization, and structure - Activity relationship studies of small molecular agonists for the orphan GPR88 receptor

GPR88 is an orphan G-protein-coupled receptor (GPCR) enriched in the striatum. Genetic deletion and gene expression studies have suggested that GPR88 plays an important role in the regulation of striatal functions and is implicated in psychiatric disorder

MODULATORS OF G PROTEIN-COUPLED RECEPTOR 88

The present disclosure is generally directed to compounds which can modulate G-protein coupled receptor 88, compositions comprising such compounds, and methods for modulating G-protein coupled receptor 88.