tert-butyl [(2S,3S)-1-{4-bromophenyl-[(1R,2R)-2-(pyridin-2-yl)cyclopropanecarbonyl]amino}-3-methylpentan-2-yl]carbamate

Base Information

Chemical Name:tert-butyl [(2S,3S)-1-{4-bromophenyl-[(1R,2R)-2-(pyridin-2-yl)cyclopropanecarbonyl]amino}-3-methylpentan-2-yl]carbamate
CAS No.:1287205-76-8
Molecular Formula:C₂₆H₃₄BrN₃O₃
Molecular Weight:516.478
Hs Code.:

Synonyms:tert-butyl [(2S,3S)-1-{4-bromophenyl-[(1R,2R)-2-(pyridin-2-yl)cyclopropanecarbonyl]amino}-3-methylpentan-2-yl]carbamate

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Chemical Property of tert-butyl [(2S,3S)-1-{4-bromophenyl-[(1R,2R)-2-(pyridin-2-yl)cyclopropanecarbonyl]amino}-3-methylpentan-2-yl]carbamate

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Technology Process of tert-butyl [(2S,3S)-1-{4-bromophenyl-[(1R,2R)-2-(pyridin-2-yl)cyclopropanecarbonyl]amino}-3-methylpentan-2-yl]carbamate

There total 12 articles about tert-butyl [(2S,3S)-1-{4-bromophenyl-[(1R,2R)-2-(pyridin-2-yl)cyclopropanecarbonyl]amino}-3-methylpentan-2-yl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1287205-75-7
(1R,2R)-2-(pyridin-2-yl)cyclopropanecarboxylic acid

: 1287206-23-8
tert-butyl {(2S,3S)-1-[(4-bromophenyl)amino]-3-methylpentan-2-yl}carbamate

: 1287205-76-8
tert-butyl [(2S,3S)-1-{4-bromophenyl-[(1R,2R)-2-(pyridin-2-yl)cyclopropanecarbonyl]amino}-3-methylpentan-2-yl]carbamate

Guidance literature:: (1R,2R)-2-(pyridin-2-yl)cyclopropanecarboxylic acid; With oxalyl dichloride; In dichloromethane; N,N-dimethyl-formamide; at 35 ℃; for 2h;

tert-butyl {(2S,3S)-1-[(4-bromophenyl)amino]-3-methylpentan-2-yl}carbamate; With triethylamine; In dichloromethane; at 20 ℃;

Reference yield: 40.0%

: tert-butyl [(2S,3S)-1-{4-bromophenyl-[2-(pyridin-2-yl)cyclopropanecarbonyl]amino}-3-methylpentan-2-yl]carbamate

: 1287205-76-8
tert-butyl [(2S,3S)-1-{4-bromophenyl-[(1R,2R)-2-(pyridin-2-yl)cyclopropanecarbonyl]amino}-3-methylpentan-2-yl]carbamate

: tert-butyl [(2S,3S)-1-{4-bromophenyl-[(1S,2S)-2-(pyridin-2-yl)cyclopropanecarbonyl]amino}-3-methylpentan-2-yl]carbamate

Guidance literature:: With ChiralPak IA column; In ethanol; hexane; Resolution of racemate;
DOI:10.1021/cn500082p

Reference yield:

: 100-69-6,25014-15-7,27476-03-5,329041-71-6
2-vinylpyridine

: 1287205-76-8
tert-butyl [(2S,3S)-1-{4-bromophenyl-[(1R,2R)-2-(pyridin-2-yl)cyclopropanecarbonyl]amino}-3-methylpentan-2-yl]carbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: cobalt(II) 5,10,15,20-tetraphenylporphyrin / toluene / 2 h / 80 °C

2.1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 2 h / 35 °C

2.2: 20 °C

With oxalyl dichloride; cobalt(II) 5,10,15,20-tetraphenylporphyrin; In dichloromethane; N,N-dimethyl-formamide; toluene;