1287262-17-2Relevant academic research and scientific papers
In vitro and in vivo antifilarial activity evaluation of 3,6-epoxy [1,5]dioxocines: A new class of antifilarial agents
Sashidhara, Koneni V.,Kumar, Abdhesh,Rao, K. Bhaskara,Kushwaha, Vikas,Saxena, Kirti,Murthy
, p. 1527 - 1532 (2012)
A series of 3,6-epoxy [1,5]dioxocines were synthesized and evaluated for their antifilarial activity against adult parasites of human lymphatic filarial parasite Brugia malayi (sub-periodic strain) in vitro. Out of these, six compounds (4a-f) possessed im
Antiplasmodial activity of novel keto-enamine chalcone-chloroquine based hybrid pharmacophores
Sashidhara, Koneni V.,Kumar, Manoj,Modukuri, Ram K.,Srivastava, Rajeev Kumar,Soni, Awakash,Srivastava, Kumkum,Singh, Shiv Vardan,Saxena,Gauniyal, Harsh M.,Puri, Sunil K.
scheme or table, p. 2971 - 2981 (2012/07/02)
A series of novel keto-enamine chalcone-chloroquine based hybrids were synthesized following new methodology developed in our laboratory. The synthesized compounds were screened against chloroquine sensitive strain (3D7) of Plasmodium falciparum in an in
Synthesis and in vitro evaluation of novel coumarin-chalcone hybrids as potential anticancer agents
Sashidhara, Koneni V.,Kumar, Abdhesh,Kumar, Manoj,Sarkar, Jayanta,Sinha, Sudhir
supporting information; experimental part, p. 7205 - 7211 (2011/01/03)
A series of coumarin-chalcone hybrids have been synthesized and evaluated for their in vitro cytotoxicity against a panel of four human cancer cell lines and normal fibroblasts (NIH3T3). Among 21 compounds screened, three compounds (23, 25 and 26) showed IC50 range from 3.59 to 8.12 μM. The most promising compound 26 showed around 30-fold more selectivity towards C33A (cervical carcinoma) cells over normal fibroblast NIH3T3 cells with an IC 50 value of 3.59 μM.
