1287286-02-5

Usage

Uses

Used in Pharmaceutical Research:
(1R)-2-azido-1-[4-(2-methylpentyloxy)phenyl]ethanamine is used as a building block for the synthesis of biologically active compounds and drug candidates due to its unique structure and properties.
Used in Organic Synthesis:
(1R)-2-azido-1-[4-(2-methylpentyloxy)phenyl]ethanamine serves as an intermediate in organic synthesis, facilitating the creation of complex organic molecules and contributing to the development of novel chemical entities.
Used in Development of Therapeutic Agents:
(1R)-2-azido-1-[4-(2-methylpentyloxy)phenyl]ethanamine is utilized in the development of potential therapeutic agents, given its capacity to be incorporated into molecules with specific biological activities.
Used in Chemical Probes for Biological Studies:
It is employed as a chemical probe for studying biological processes, enabling researchers to gain insights into the mechanisms of various diseases and biological phenomena.

Upstream product

• 1287285-61-3 methyl (2R)-2-{[(tert-butoxy)carbonyl]amino}-2-{4-[(2-methylpentyl)oxy]phenyl}acetate 
• 1287286-00-3 tert-butyl N-[(1R)-2-bromo-1-{4-[(2-methylpentyl)oxy]phenyl}-ethyl]carbamate 
• 1286280-72-5 tert-butyl (1R)-2-hydroxy-1-[4-(2-methylpentyloxy)phenyl]ethylcarbamate 
• 57591-61-4 methyl (R)-2-amino-2-(4-hydroxyphenyl)acetate hydrochloride 
• 143323-49-3 (R)-methyl 2-((tert-butoxycarbonyl)amino)-2-(4-hydroxyphenyl)acetate 

Downstream Products

• 1287286-06-9 (2S)-N-{(1R)-2-azido-1-[4-(2-methylpentyloxy)phenyl]ethyl}-2-phenylpropanamide 
• 1287285-96-4 (2S)-N-{(1R)-2-amino-1-[4-(2-methylpentyloxy)phenyl]ethyl}-2-phenylpropanamide 
• 1287286-09-2 (2S)-N-((1R)-2-(dimethylamino)-1-(4-(2-methylpentyloxy)phenyl)ethyl)-2-phenylpropanamide trifluoroacetate 
• 1287286-10-5 (2S)-N-((1R)-2-(cyclopropylmethylamino)-1-(4-(2-methylpentyloxy)phenyl)ethyl)-2-phenylpropanamide 
• 1287286-26-3 (2S)-N-((1R)-2-((1-aminocyclopentyl)methylamino)-1-(4-(2-methylpentyloxy)phenyl)ethyl)-2-phenylpropanamide 
• 1287286-29-6 t-butyl 1-(((2R)-2-(4-(2-methylpentyloxy)phenyl)-2-((S)-2-phenylpropanamido)ethylamino)methyl)-cyclopentylcarbamate 
• 1287286-38-7 (2S,3S)-2-amino-3-methyl-N-((2R)-2-(4-(2-methylpentyloxy)phenyl)-2-((S)-2-phenylpropanamido)ethyl)pentanamide 
• 1287286-39-8 t-butyl (2S,3S)-3-methyl-1-((2R)-2-(4-(2-methylpentyloxy)phenyl)-2-((S)-2-phenylpropanamido)ethylamino)-1-oxopentan-2-ylcarbamate 
• 1287286-59-2 (2S)-N-((1R)-1-(4-(2-methylpentyloxy)phenyl)-2-morpholinoethyl)-2-phenylpropanamide trifluoroacetate 

Relevant academic research and scientific papers

Design, synthesis and pharmacological evaluation of 4-hydroxyphenylglycine and 4-hydroxyphenylglycinol derivatives as GPR88 agonists

The orphan receptor GPR88 is an attractive therapeutic target because of its implications in a number of basal ganglia-associated disorders. To date, pharmacological characterization of GPR88 has been limited due to the lack of potent and selective agonists and antagonists appropriate for CNS investigations. We have previously reported that GPR88 couples to Gαiproteins and modulates cAMP levels upon treatment with a small molecule agonist 2-PCCA. Recently, another chemotype of GPR88 agonist, represented by 2-AMPP [(2S)-N-((1R)-2-amino-1-(4-(2-methylpentyloxy)-phenyl)ethyl)-2-phenylpropanamide], has also been discovered. In this report, a new series of 2-AMPP structurally related 4-hydroxyphenylglycine and 4-hydroxyphenylglycinol derivatives have been designed and evaluated for agonist activity at GPR88. The structure-activity relationship (SAR) studies suggest that the amine group in 2-AMPP can be replaced by hydroxyl, ester and amide groups, resulting in analogues with good to moderate potency, whereas the phenyl group on the amide cap is essential for activity and has limited size, shape and electronic tolerance.

MODULATORS OF G PROTEIN-COUPLED RECEPTOR 88

The present disclosure is generally directed to compounds which can modulate G-protein coupled receptor 88, compositions comprising such compounds, and methods for modulating G-protein coupled receptor 88.