57591-61-4

Basic information

• Product Name: (R)-Amino-(4-hydroxyphenyl)acetic acid methyl ester hydrochloride
• Synonyms: D-P-HYDROXY-PHENYLGLYCINE METHYL ESTER;D-4-Hydroxyphenylglycine methyl ester HCl;D-(-)-P-HYDROXYPHENYLGLYCINE METHYL ESTE;D-4-Hydroxyphenylglycine methyl ester hydrochloride;D-p-hydroxyphenyl-glycine methyl hydrochloride;(R)-Amino-(4-hydroxyphenyl)acetic acid methyl ester hydrochloride;D-p-Hydroxyphenylglycine methyl ester hydrochloride;(R)-methyl 2-amino-2-(4-hydroxyphenyl)acetate hydrochloride
• CAS NO: 57591-61-4
• Molecular Formula: C₉H₁₁NO₃*ClH
• Molecular Weight: 217.65
• EINECS: 1308068-626-2
• Mol File: 57591-61-4.mol
• Article Data: 15

Chemical Properties

• Melting Point: 187-190 °C(lit.)
• Boiling Point: 335.1 °C at 760 mmHg
• Flash Point: 156.5 °C
• Appearance: /Solid
• Vapor Pressure: 1.59E-05mmHg at 25°C
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Solubility: Aqueous Acid (Slightly), DMSO (Slightly, Heated), Methanol (Slightly)
• Stability: Hygroscopic
• CAS DataBase Reference: (R)-Amino-(4-hydroxyphenyl)acetic acid methyl ester hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-Amino-(4-hydroxyphenyl)acetic acid methyl ester hydrochloride(57591-61-4)
• EPA Substance Registry System: (R)-Amino-(4-hydroxyphenyl)acetic acid methyl ester hydrochloride(57591-61-4)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 57591-61-4(Hazardous Substances Data)

Usage

Chemical Properties

White to Off-White Solid

Uses

D-4-Hydroxyphenylglycine Methyl ester hydrochloride is used in the production of antiviral peptides and beta-lactam anti-biotics.

InChI:InChI=1/C9H11NO3.ClH/c1-13-9(12)6-10-7-2-4-8(11)5-3-7;/h2-5,10-11H,6H2,1H3;1H

Upstream product

• 37763-23-8 D-2-p-hydroxyphenylglycine methyl ester 
• 67-56-1 methanol 
• 22818-40-2 D-4-hydroxyphenylglycine 

Downstream Products

• 1005002-00-5 (R)-2-amino-2-[4-(nonafluorobutanesulfonyloxy)phenyl]-1,1-diphenylethanol 
• 906552-97-4 [1-(4-{4'-[4-(1-tert-butoxycarbonylamino-2-hydroxy-ethyl)-phenoxy]-[2,2']bipyridinyl-4-yloxy}-phenyl)-2-hydroxy-ethyl]-carbamic acid tert-butyl ester 
• 906552-95-2 [1-(4-{4'-[4-(1-tert-butoxycarbonylamino-2-hydroxy-ethyl)-phenoxy]-1,1'-dioxy-[2,2']bipyridinyl-4-yloxy}-phenyl)-2-hydroxy-ethyl]-carbamic acid tert-butyl ester 
• 691889-35-7 (R)-N-(t-butoxycarbonyl)-4-(t-butyldimethylsiloxy)phenylglycinol 
• 600738-20-3 4-tert-butoxy-R-phenylglycinol 
• 600738-19-0 N-benzyloxycarbonyl-4-tert-butoxy-R-phenylglycinol 
• 600738-17-8 N-benzyloxycarbonyl-4-tert-butoxy-R-phenylglycine methyl ester 
• 600738-18-9 N-benzyloxycarbonyl-4-tert-butoxy-R-phenylglycine 
• 1195785-28-4 C₂₄H₂₈FN₃O₈ 
• 1287286-67-2 (S)-N-{(R)-1-[4-((S)-2-methyl-butoxy)-phenyl]-2-propylamino-ethyl}-2-phenyl-propionamide 
• 1286280-72-5 tert-butyl (1R)-2-hydroxy-1-[4-(2-methylpentyloxy)phenyl]ethylcarbamate 
• 1287285-87-3 t-butyl (1R)-2-hydroxy-2-methyl-1-(4-(2-methylpentyloxy)phenyl)-propylcarbamate 
• 1287285-92-0 (1R)-1-amino-2-methyl-1-(4-(2-methylpentyloxy)phenyl)propan-2-ol trifluoroacetate 
• 1287285-82-8 (2S)-N-((1R)-2-hydroxy-2-methyl-1-(4-(2-methylpentyloxy)phenyl)propyl)-2-phenylpropanamide 

Relevant articles and documents

Preparation method of (-) - Cytoxazone and (+) -4 - epi-Cytoxazone

The preparation method of (-) - Cytoxazone and (+) -4 - epi-Cytoxazone takes D - p-hydroxyphenylglycine as a raw material, the intermediate 2 is obtained through methyl esterification reaction under catalysis of thionyl chloride, and then the amino is protected with Boc anhydride to obtain the intermediate 3. The compound 4 is obtained by using potassium carbonate as a base and reacting with methyl iodide under reflux conditions. The methyl ester was reduced with sodium borohydride/lithium chloride to give the primary alcohol compound 5. An intermediate IBX is then obtained with 6 primary alcohol, then reacted with acetone cyanohydrin SN2 to give intermediate 7, and the intermediate 8 is obtained by reacting with the methanol solution of hydrogen chloride to obtain two five-membered ring compound compounds 9 and 10, respectively, with sodium borohydride to obtain (-) - Cytoxazone and its isomers (+) -4 - epi-Cytoxtoxtoxtoxol, respectively.

Intermediate of RORgamma inhibitor and preparation method thereof

The invention belongs to the technical field of drugs, in particular to an intermediate of a RORgamma inhibitor and a preparation method thereof. The intermediate is as shown in a formula (I). The method has the advantages of being easily available in raw material, concise in process, economic and environment-friendly, high in yield and the like. The formula is as shown in the description.

NOVEL ANTIESTROGENIC HETEROCYCLIC COMPOUNDS

The present invention provides novel heterocyclic compounds of Formula I wherein A, B, E, ring Z, Y, L, ring X, D, m, n, R7 and R8 are as defined in the specification as estrogen receptor antagonists/degraders. The compound of Formula I can be used for the treatment of cancers mediated by estrogen receptors. (Formula I ).