128735-67-1

Upstream product

• 128735-66-0 (4R,5S)-5-((2R,3S,6S)-3,4-Dimethyl-5,7-dioxo-2-phenyl-[1,4]oxazepan-6-yl)-4-ethyl-2-hydroxy-3-oxo-cyclopent-1-enecarboxylic acid methyl ester 
• 128735-69-3 (4S,5R)-5-{[(2-Acetoxy-1-methyl-2-phenyl-ethyl)-methyl-carbamoyl]-methoxycarbonyl-methyl}-4-ethyl-2-methoxy-3-oxo-cyclopent-1-enecarboxylic acid methyl ester 

Downstream Products

• 130253-47-3 N-((1S,2R)-2-Acetoxy-1-methyl-2-phenyl-ethyl)-N-methyl-malonamic acid methyl ester 
• 130253-24-6 (3R,4R,5R)-3-Acetoxy-5-{[((1S,2R)-2-acetoxy-1-methyl-2-phenyl-ethyl)-methyl-carbamoyl]-methoxycarbonyl-methyl}-4-ethyl-2-oxo-cyclopentanecarboxylic acid methyl ester 

Relevant academic research and scientific papers

Asymmetric total synthesis from cyclopentene-1,2-diones: Characterisation of a diastereomerically pure Michael adduct

A key cyclopentenolone intermediate in the asymmetric synthesis of alkaloids and seco-iridoids has been prepared from reaction of a chiral 5,7-dioxoperhydro-1,4-oxazepine with a cyclopentene-1,2-dione dimer; the absolute configuration at the induced chiral centres has been assigned from n.O.e. experiments.

Asymmetric total synthesis of alkaloids and seco-iridoids

A chiral cyclopentenolone from Michael addition of an oxazepine derived from ephedrine to a cyclopentene-1,2-dione has been converted into pure enantiomers of established synthetic precursors to alkaloids and seco-iridoids via a novel exchange which recov