128753-46-8Relevant academic research and scientific papers
Synthesis of 1-amino-2,2-dialkylcyclopropanecarboxylic acids via base-induced cyclization of γ-chloro-α-imino ester
Boeykens,De Kimpe,Abbaspour Tehrani
, p. 6973 - 6985 (2007/10/02)
β-Chloro ketones were oxidatively transformed into α-keto carboxylic esters and condensed with primary amines in the presence of titanium(IV) chloride. Base-induced cyclization of the resulting γ-chloro-α-imino esters, incorporating suitable N-substituent
Synthesis of 2,2-Dialkyl-1-aminocyclopropanecarboxylic Acids from α-Chloro Ketimines
Kimpe, Norbert De,Sulmon, Paul,Brunet, Pascal
, p. 5777 - 5784 (2007/10/02)
2,2-Dialkyl-1-aminocyclopropanecarboxylic acids, abbreviated as 2,2-dialkyl Acc's, are potential plant growth regulators which were synthesized by ring closure of α-chloro imines.The synthetic scheme leading to these Acc analogues entails a newly developed regiospecific synthesis of tertiary α-chloro ketimines, the trapping with cyanide of a transient Favorskii derived cyclopropylideneamine, and the hydrolytic conversion of 1-(N-tert-butylamino)-2,2-dialkylcyclopropanecarbonitriles into the title compounds.
