1287678-41-4Relevant academic research and scientific papers
N-Heterocyclic-carbene-catalyzed asymmetric oxidative hetero-diels-alder reactions with simple aliphatic aldehydes
Zhao, Xiaodan,Ruhl, Kyle E.,Rovis, Tomislav
supporting information, p. 12330 - 12333 (2013/02/23)
An efficient enantioselective approach to form trans lactams and cis lactones in up to 98 % yield with greater than 99 % ee, and greater than 20:1 d.r. using simple aliphatic aldehydes has been developed. The process involves a new pathway to generate enolate intermediates from aliphatic aldehydes by oxidation and deprotonation. NHC=N-heterocyclic carbene, Ts=4-toluenesulfonyl. Copyright
Chiral N-heterocyclic carbene-catalyzed generation of ester enolate equivalents from a,β-unsaturated aldehydes for enantioselective Diels-Alder reactions
Kaeobamrung, Juthanat,Kozlowski, Marisa C.,Bode, Jeffrey W.
scheme or table, p. 20661 - 20665 (2011/10/02)
The catalytic generation of chiral ester enolate equivalents from α,β-unsaturated aldehydes with chiral N-hetereocyclic carbene catalysts makes possible highly enantioselective hetero-Diels- Alder reactions. The reactions proceed under simple, mild condit
