1287682-35-2

Upstream product

• 52670-38-9 2-ethynylaniline 
• 622-79-7 benzyl azide 
• 100-39-0 benzyl bromide 
• 100-44-7 benzyl chloride 

Downstream Products

• 1263862-48-1 N-(2-(1-benzyl-1H-1,2,3-triazol-4-yl)phenyl)acetamide 

Relevant academic research and scientific papers

A straightforward and sustainable synthesis of 1,4-disubstituted 1,2,3-triazoles: Via visible-light-promoted copper-catalyzed azide-alkyne cycloaddition (CuAAC)

A simple and green synthesis of 1,4-disubstituted 1,2,3-triazoles through the effective reduction of copper(ii) assisted by organic dyes and promoted by visible light was developed. This reaction was performed under very mild conditions, using water as solvent, under a non-inert atmosphere, with low catalyst precursor loading, and in the absence of any additive. Copper and solvent recycling was successfully achieved at least three times without loss of efficiency. In addition, a safer one-step one-pot procedure was designed with very good yield.

Azide–Alkyne Cycloaddition (CuAAC) in Alkane Solvents Catalyzed by Fluorinated NHC Copper(I) Complex

A highly efficient and environmentally benign protocol for copper-catalyzed alkyne–azide cycloaddition (CuAAC) in industrially important alkane solvents was developed. New copper(I) complexes bearing NHC ligands decorated with bulky hexafluoroisopropylalk

Synthesis of 1,2,3-triazoles in the presence of mixed Mg/Fe oxides and their evaluation as corrosion inhibitors of API 5L X70 steel submerged in HCl

In this work, the catalytic capacity of a Mg/Fe layered double hydroxide (LDH) and its mixed oxides to perform Huisgen cycloaddition was studied. The catalytic process was performed in the presence of sodium ascorbate, which was determinant for the success of the 1,3-cycloaddition. The obtained triazoles were evaluated as corrosion inhibitors using electrochemical impedance spectroscopy under static conditions, showing an inhibition efficiency higher than 95% at 50 ppm for some of the triazoles studied. According to the Langmuir isotherm, all the compounds synthesized and analysed exhibit a chemisorption process. Finally, the corrosion process when submerging a steel bar in 1 M HCl was studied using SEM-EDS. This experiment showed that the corrosion process decreases considerably in the presence of 50 ppm of the organic inhibitor.

Heterogeneous Photocatalytic Click Chemistry

Copper-doped semiconductors are designed to photoassist the alkyne-azide cycloaddition catalysis by Cu(I). Upon irradiation, injection of electrons from the semiconductor into copper oxide nanostructures produces the catalytic Cu(I) species. The new catalysts are air- and moisture-tolerant and can be readily recovered after use and reused several times.

The copper-nicotinamide complex: Sustainable applications in coupling and cycloaddition reactions

The crystalline copper(ii)-nicotinamide complex, synthesized via simple mixing of copper chloride and nicotinamide solution at room temperature, catalyzes the C-S, C-N bond forming and cycloaddition reactions under a variety of sustainable reaction conditions.

Organic synthesis via magnetic attraction: Benign and sustainable protocols using magnetic nanoferrites

Magnetic nano-catalysts have been prepared using simple modification of iron ferrites. The nm size range of these particles facilitates the catalysis process, as an increased surface area is available for the reaction; the easy separation of the catalysts by an external magnet and their recovery and reuse are additional beneficial attributes. Glutathione bearing nano-ferrites have been used as organocatalysts for the Paal-Knorr reaction and homocoupling of boronic acids. Nanoferrites, post-synthetically modified by ligands, were used to immobilize nanometals (Cu, Pd, Ru, etc.) which enabled the development of efficient, sustainable and green procedures for azide-alkynes-cycloaddition (AAC) reactions, C-S coupling, O-allylation of phenol, Heck-type reactions and hydration of nitriles.

A versatile solvent-free azide-alkyne click reaction catalyzed by in situ generated copper nanoparticles

A general, high-yielding and efficient methodology for the copper catalyzed azide-alkyne cycloaddition (CuAAC) reaction catalyzed by in situ generated copper nanoparticles (CuNPs) or their clusters is reported. This simple reaction is facile in water, org

Cationic and neutral (Ar-BIAN)copper(I) complexes containing phosphane and arsane ancillary ligands: Synthesis, molecular structure and catalytic behaviour in cycloaddition reactions of azides and alkynes

A series of new cationic and neutral (Ar-BIAN)copper(I) complexes [in which Ar-BIAN = bis(aryl)acenaphthenequinonediimine] was synthesised and characterised by elemental analysis, 1D and 2D NMR spectroscopy and single-crystal X-ray diffraction. The cation

A highly active magnetically recoverable nano ferrite-glutathione-copper (nano-FGT-Cu) catalyst for Huisgen 1,3-dipolar cycloadditions

1,2,3-Triazoles were synthesized in water using magnetically recoverable heterogeneous Cu catalyst via one-pot multi component reaction using MW irradiation. Aqueous reaction medium, easy recovery of the catalyst using an external magnet, efficient recycl

Conventional and microwave assisted synthesis of 1,4-disubstituted 1,2,3-triazoles from Huisgen cycloaddition

In this paper the synthesis of a library of new 1,4-disubstituted 1,2,3-triazoles 1, with a variety of additional functional groups on its structure, from an in situ generated benzyl azide 2 and different alkynes and dialkynes 3 is reported. Optimal exper