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1287693-64-4

1287693-64-4

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1287693-64-4 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1287693-64-4 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,8,7,6,9 and 3 respectively; the second part has 2 digits, 6 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1287693-64:
(9*1)+(8*2)+(7*8)+(6*7)+(5*6)+(4*9)+(3*3)+(2*6)+(1*4)=214
214 % 10 = 4
So 1287693-64-4 is a valid CAS Registry Number.

1287693-64-4Downstream Products

1287693-64-4Relevant articles and documents

Discovery of INCB10820/PF-4178903, a potent, selective, and orally bioavailable dual CCR2 and CCR5 antagonist

Zheng, Changsheng,Cao, Ganfeng,Xia, Michael,Feng, Hao,Glenn, Joseph,Anand, Rajan,Zhang, Ke,Huang, Taisheng,Wang, Anlai,Kong, Ling,Li, Mei,Galya, Laurine,Hughes, Robert O.,Devraj, Rajesh,Morton, Phillip A.,Rogier, D. Joseph,Covington, Maryanne,Baribaud, Fred,Shin, Niu,Scherle, Peggy,Diamond, Sharon,Yeleswaram, Swamy,Vaddi, Kris,Newton, Robert,Hollis, Greg,Friedman, Steven,Metcalf, Brian,Xue, Chu-Biao

, p. 1442 - 1446 (2011/04/22)

We report the discovery of a potent, selective, and orally bioavailable dual CCR2 and CCR5 antagonist (3S,4S)-N-[(1R,3S)-3-isopropyl-3-({4-[4- (trifluoromethyl)pyridin-2-yl]piperazin-1-yl}carbonyl)cyclopentyl] -3-methoxytetrahydro-2H-pyran-4-amine (19). After evaluation in 28-day toxicology studies, compound 19 (INCB10820/PF-4178903) was selected as a clinical candidate.

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