1287702-06-0Relevant academic research and scientific papers
Biomimetic synthesis of hyperolactones
Wu, Yingying,Du, Chao,Hu, Congcong,Li, Ying,Xie, Zhixiang
, p. 4075 - 4081 (2011/06/26)
Through a biomimetic pathway, hyperolactone D, 4-hydroxyhyperolactone D, and hyperolactone C were synthesized from methyl acetoacetate via Weilers dianion method, asymmetric allylic alkylation, biomimetic lactonization, oxidation, and cyclization. The stereochemistry of the quaternary carbon was controlled efficiently by Palladium-catalyzed asymmetric allylic alkylation. This strategy was also used for the synthesis of hyperolactone B.
