1289155-41-4

Upstream product

• 105-45-3 acetoacetic acid methyl ester 
• 100-52-7 benzaldehyde 
• 53063-63-1 5-hydroxy-3-oxo-5-phenyl-valeric acid methyl ester 
• 1838-94-4 isoprene epoxide 

Downstream Products

• 1287701-98-7 methyl (E,4R)-4-methyl-2-styryl-4-vinyl-2,3-dihydrofuran-3-carboxylate 
• 1287701-99-8 (4R)-3-(3-hydroxy-3-phenylpropanoyl)-4-methyl-4-vinyldihydrofuran-2(3H)-one 
• 1287702-00-4 (3R,4S)-3-hydroxy-3-(3-hydroxyl3-phenylpropanoyl)-4-methyl-4-vinyldihydrofuran-2(3H)-one 
• 1287702-06-0 (3S,4S)-3-hydroxy-3-(3-hydroxyl3-phenylpropanoyl)-4-methyl-4-vinyldihydrofuran-2(3H)-one 
• 1174170-63-8 3-hyproxyhyperolactone D 
• 1289155-42-5 (3R,4S,Z)-3-hydroxy-3-(3-hydroxy-3-phenylacryloyl)-4-methyl-4-vinyldihydrofuran-2(3H)-one 
• 165170-94-5 (5S,9S)-9-methyl-2-phenyl-9-vinyl-1,7-dioxaspiro[4.4]non-2-ene-4,6-dione 

Relevant academic research and scientific papers

Biomimetic synthesis of hyperolactones

Through a biomimetic pathway, hyperolactone D, 4-hydroxyhyperolactone D, and hyperolactone C were synthesized from methyl acetoacetate via Weilers dianion method, asymmetric allylic alkylation, biomimetic lactonization, oxidation, and cyclization. The stereochemistry of the quaternary carbon was controlled efficiently by Palladium-catalyzed asymmetric allylic alkylation. This strategy was also used for the synthesis of hyperolactone B.