128778-29-0Relevant academic research and scientific papers
The Asymmetric Aldol Reaction of Tosylmethyl Isocyanide and Aldehydes Catalyzed by Chiral Silver(I) Complexes
Sawamura, Masaya,Hamashima, Hitoshi,Ito, Yoshihiko
, p. 5935 - 5936 (2007/10/02)
The asymmetric aldol reaction of tosylmethyl isocyanide and aldehydes in the presence of 1 mol percent of chiral silver(I) catalysts gave optically active 5-alkyl-4-tosyl-2-oxazolines (up to 86percent ee), which were converted to optically active α-alkyl-β-(N-methylamino)ethanols by LiAlH4 reduction.
ASYMMETRIC ALDOL REACTION OF α-ISOCYANOACETAMIDES WITH ALDEHYDES CATALYZED BY A CHIRAL FERROCENYLPHOSPHINE-GOLD(I) COMPLEX
Ito, Yoshihiko,Sawamura, Masaya,Kobayashi,Masaaki,Hayashi, Tamio
, p. 6321 - 6324 (2007/10/02)
Aldol reaction of N,N-dialkyl-α-isocyanoacetamides with primary alkyl aldehydes in the presence of 0.5-1 molpercent of a chiral (aminoalkyl)ferrocenylphosphine-gold(I) catalyst proceeded with high enantio- and diastereoselectivity to give trans-5-alkyl-2-oxazoline-4-carboxamides of up to 98.6percent ee, which were converted into optically active threo-β-hydroxyamino acids.
