1287785-26-5

Basic information

• Product Name: N-{2-[7-(3-Isopropylphenyl)-1,6-dihydro-2H-indeno[5,4-b]-furan-8-yl]ethyl}acetaMide
• Synonyms: N-{2-[7-(3-Isopropylphenyl)-1,6-dihydro-2H-indeno[5,4-b]-furan-8-yl]ethyl}acetaMide
• CAS NO: 1287785-26-5
• Molecular Formula: C₂₄H₂₇NO₂
• Molecular Weight: 361.47668
• Mol File: 1287785-26-5.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-{2-[7-(3-Isopropylphenyl)-1,6-dihydro-2H-indeno[5,4-b]-furan-8-yl]ethyl}acetaMide(CAS DataBase Reference)
• NIST Chemistry Reference: N-{2-[7-(3-Isopropylphenyl)-1,6-dihydro-2H-indeno[5,4-b]-furan-8-yl]ethyl}acetaMide(1287785-26-5)
• EPA Substance Registry System: N-{2-[7-(3-Isopropylphenyl)-1,6-dihydro-2H-indeno[5,4-b]-furan-8-yl]ethyl}acetaMide(1287785-26-5)

Safety Data

• Hazardous Substances Data: 1287785-26-5(Hazardous Substances Data)

Upstream product

• 196597-78-1 1,2,6,7-tetrahydro-8H-indeno[5,4-b]-furan-8-one 
• 1287785-11-8 N-[2-(7-bromo-1,6-dihydro-2H-indeno[5,4-b]furan-8-yl)-ethyl]acetamide 
• 216019-28-2 3-isopropylphenylboronic acid 
• 1029134-74-4 C₁₃H₁₅NO 
• 221530-44-5 2-(1,2,6,7-tetrahydro-8H-indeno[5,4-b]furan-8-ylidene)acetonitrile 

Relevant articles and documents

1,6-dihydro-2H-indeno[5,4-b]furan derivatives: Design, synthesis, and pharmacological characterization of a novel class of highly potent MT 2-selective agonists

Figure Presented. A novel series of 1,6-dihydro-2H-indeno[5,4-b]furan derivatives were designed and synthesized as MT2-selective ligands. This scaffold was identified as a potent mimic of the 5-methoxy indole core of melatonin, and introduction of a cyclohexylmethyl group at the 7-position of this scaffold afforded an MT2-selective ligand 15 (Ki = 0.012 nM) with high MT1/MT2 selectivity (799). Compound 15 was identified as a potent full agonist for the MT2 subtype and exhibited reentrainment effects to a new light/dark cycle in ICR mice at 3-30 mg/kg. This result demonstrated the involvement of the MT2 receptors in chronobiotic activity.