1287794-79-9

Upstream product

• 923033-24-3 phenol, 3,4,5-trifluoro-2-nitro 
• 99627-05-1 3,4,5-trifluorophenol 
• 29632-74-4 2-fluro-4-iodoaniline 
• 1287794-78-8 benzene, 1,2,3-trifluoro-4-nitro-5-(2-propen-1-yloxy) 

Downstream Products

• 1287794-93-7 (3-allyloxy-6-fluoro-5-methoxy-2-nitrophenyl)-(2-fluoro-4-iodophenyl)-amine 
• 1287794-98-2 (1-allyl-N-(6-(allyloxy)-3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)phenyl)cyclopropane-1-sulfonamide) 
• 1287794-64-2 C₂₀H₂₁F₂IN₂O₆S 
• 1287794-60-8 10,11-difluoro-12-((2-fluoro-4-iodophenyl)amino)-5,6-dihydroxy-4,5,6,7-tetrahydro-1H-spiro[benzo[b][1,5,4]oxathiazecine-3,1'-cyclopropane]2,2-dioxide 
• 1287794-57-3 C₂₀H₁₉F₂IN₂O₄S 
• 1287794-53-9 C₁₉H₁₆F₃IN₂O₃S 
• 1287795-02-1 C₂₂H₂₃F₂IN₂O₄S 
• 1287794-92-6 6-allyloxy-3-fluoro-N₂-(2-fluoro-4-iodophenyl)-4-methoxybenzene-1,2-diamine 
• 1287794-88-0 6-allyloxy-3,4-difluoro-N₂-(2-fluoro-4-iodophenyl)-benzene-1,2-diamine 
• 1287794-72-2 C₁₉H₁₉F₃IN₃O₄S 
• 1287794-76-6 C₁₉H₁₉F₃IN₃O₄S 
• 1287794-71-1 C₁₉H₁₈F₃IN₂O₃S 

Relevant academic research and scientific papers

Macrocyclic MEK1/2 inhibitor with efficacy in a mouse model of cardiomyopathy caused by lamin A/C gene mutation

Signaling mediated by extracellular signal-regulated kinases 1 and 2 (ERK1/2) is involved in numerous cellular processes. Mitogen-activated protein kinase kinases (MEK1/2) catalyze the phosphorylation of ERK1/2, converting it into an active kinase that re

NOVEL MEK INHIBITORS, USEFUL IN THE TREATMENT OF DISEASES

The invention pertains to compound of Formula (I) wherein X, Y, Z, R1, R2, R3, R4, A and A' are as described hereinabove. Formula (I) and (II) compounds can be used in pharmaceutical compositions, useful for the treatment of diseases