128797-15-9Relevant academic research and scientific papers
Annulation by Sequential Doubla Michael Reaction; Synthesis of Decalones and Its Application to the Syntheses of ε-Cadinene, Khusitone and Khusilal
Hagiwara, Hisahiro,Akama, Tsutomu,Okano, Akihiro,Uda, Hisashi
, p. 2173 - 2184 (2007/10/02)
Reaction of kinetic enolates or the trimethylsilyl enol ethers of 1-acetylcyclohexenes with α,β-unsaturated carbonyl compounds affords 4-substituted 1-decalone derivatives under basic or Lewis acidic conditions.The reaction with acrylates of chiral alcohols has achieved 70percent diastereoselection.Application of these reactions has enabled syntheses of ε-cadinene, khusitone and khusial to be accomplished.
Asymmetric Two-Fold Michael Reaction. Synthesis of Optically Active 4-Substituted 1-Decalones from Trimethylsilyl Enol Ether of 1-Acetylcyclohexene
Hagiwara, Hisahiro,Akama, Tsutomu,Okano, Akihiro,Uda, Hisashi
, p. 2149 - 2152 (2007/10/02)
Acrylates having a chiral auxiliary react with the trimethylsilyl enol ether of 1-acetylcyclohexene in the presence of Et2AlCl to give 4-substituted 1-decalones with 0-70percent diastereoselectivity.The absolute stereostructure of the decalones have been determined by applying the exciton chirality method to the dibenzoate derivative.
