128799-85-9Relevant academic research and scientific papers
Facile synthesis of 4-acylamino and 4-sulphonamido β-lactams
Thiagarajan,Puranik,Deshmukh,Bhawal
, p. 7811 - 7816 (2007/10/03)
The cycloaddition reaction of trisubstituted amidines (7a-f) with acid chlorides in presence of triethylamine gave 4-acylamino and 4-sulphonamido-trans-β-lactams (9a-h) in very good yields. Similarly N,N'-diarylamidines (5a-d) on reaction with 2 equiv. of acid chlorides (8a,b) gave 4-acylamino-trans-β-lactams (10a-e) via in situ generated acylamidines followed by cycloaddition reaction. (C) 2000 Elsevier Science Ltd.
Amidines. I. Hydrolysis of N1-acyl- and N1-tosyl-N1,N2-diarylamidines
Ono,Tamura
, p. 590 - 596 (2007/10/02)
In acid hydrolysis of N1-acyl-N1,N2-diarylamidines, a water molecule attacked exclusively the amidine central carbon, and the reaction proceeded in parallel through two pathways. One of them leads to the formation of two N-acylarylamines, and the other leads to the formation of N,N-diacylarylamine and arylamine. Acid hydrolysis of N1-tosyl-N1,N2-diarylamidine was also examined. The results were similar to those of the hydrolysis of N1-acyl-N1,N2-diarylamidines. Alkaline hydrolysis and alcoholysis of N1-acyl-N1,N2-diarylamidines occurred almost exclusively at the amide carbonyl group to give N1,N2-diarylamidines and carboxylic acids or their esters. The effects of structural change and the aryl substituents on the rate and direction of the reaction were examined.
