128851-73-0

Basic information

• Product Name: 6-Bromobenzofuran
• Synonyms: BENZOFURAN, 6-BROMO-;6-Bromo-1-benzofuran;6-Bromobenzo[b]furan;6-Bromo-benzofuran
• CAS NO: 128851-73-0
• Molecular Formula: C₈H₅BrO
• Molecular Weight: 197.0287
• Product Categories: Aromatics;Heterocycles
• Mol File: 128851-73-0.mol
• Article Data: 19

Chemical Properties

• Boiling Point: 234℃
• Flash Point: 95℃
• Appearance: /
• Density: 1.608
• Storage Temp.: 2-8°C
• Solubility: Chloroform, Dichloromethane, Ethyl Acetate
• Stability: Volatile
• CAS DataBase Reference: 6-Bromobenzofuran(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Bromobenzofuran(128851-73-0)
• EPA Substance Registry System: 6-Bromobenzofuran(128851-73-0)

Safety Data

• Hazardous Substances Data: 128851-73-0(Hazardous Substances Data)

Usage

Chemical Properties

Light Yellow Oil

Upstream product

• 591-20-8 3-Bromophenol 
• 204452-94-8 2-(3-bromophenoxy)acetaldehyde diethyl acetal 

Downstream Products

• 123297-88-1 benzofuran-6-carboxaldehyde 
• 17450-68-9 benzo[b]furan-6-carbonitrile 
• 286836-34-8 1-(benzofuran-6-yl)propan-2-one 
• 445303-12-8 6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-dihydrobenzofuran 
• 865760-13-0 1-(benzofuran-6-yl)ethan-1-one 
• 1025967-78-5 (S)-2-(2-(benzofuran-6-carbonyl)-5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxamido)-3-(3-(methylsulfonyl)phenyl)propanoic acid 
• 77095-51-3 benzofuran-6-carboxylic acid 
• 588703-29-1 methyl benzofuran-6-carboxylate 

Relevant articles and documents

Five-membered heterocyclic oxo carboxylic acid compound and medical application thereof

The invention relates to a five-membered heterocyclic oxo carboxylic acid compound and a medical application thereof. Specifically, the invention relates to a compound, a pharmaceutical salt, a prodrug, a hydrate, a solvate or a crystal form as shown in a formula (I), and also relates to a preparation method of the compound, a pharmaceutical composition containing the compound and an application of the pharmaceutical composition as a secretion regulator of interferon type I, especially as an STING agonist in preparation of medicines for preventing and/or treating I-type interferon related diseases.

Pyrimidone compound and application thereof

The invention discloses a pyrimidone compound, pharmaceutically acceptable salt and solvate thereof, and provides a method for preparing the compounds, a composition containing the compounds and medicinal application of the compounds in preparation of medicines for treating diseases or disorders related to EED protein and/or PRC2 protein complex action mechanisms.

Biocatalytic Strategy for Highly Diastereo- and Enantioselective Synthesis of 2,3-Dihydrobenzofuran-Based Tricyclic Scaffolds

2,3-Dihydrobenzofurans are key pharmacophores in many natural and synthetic bioactive molecules. A biocatalytic strategy is reported here for the highly diastereo- and enantioselective construction of stereochemically rich 2,3-dihydrobenzofurans in high enantiopurity (>99.9% de and ee), high yields, and on a preparative scale via benzofuran cyclopropanation with engineered myoglobins. Computational and structure-reactivity studies provide insights into the mechanism of this reaction, enabling the elaboration of a stereochemical model that can rationalize the high stereoselectivity of the biocatalyst. This information was leveraged to implement a highly stereoselective route to a drug molecule and a tricyclic scaffold featuring five stereogenic centers via a single-enzyme transformation. This work expands the biocatalytic toolbox for asymmetric C–C bond transformations and should prove useful for further development of metalloprotein catalysts for abiotic carbene transfer reactions.