128863-72-9

Upstream product

• 92841-65-1 (4R,5S)-1,5-dimethyl-4-phenylimidazolidin-2-one 
• 128947-01-3 (4R,5S)-3-[(2E)-2-butenoyl]-1,5-dimethyl-4-phenyl-2-imidazolidinone 
• 1730-25-2 allylmagnesium bromide 
• 51851-79-7 diisopropyl allylboronate 
• 2622-05-1 allylmagnesium bromide 

Downstream Products

• 75277-87-1 (R)-3-methyl-hex-5-enoic acid methyl ester 
• 92841-65-1 (4R,5S)-1,5-dimethyl-4-phenylimidazolidin-2-one 
• 25913-87-5 (R)-3-Methyl-5-hexen-1-ol 
• 128432-05-3 (R)-3-methylhex-5-enoic acid 

Relevant academic research and scientific papers

Asymmetric 1,4-addition of Grignard reagents to chiral α,β-unsaturated imides in the presence of Lewis acids

The asymmetric 1,4 addition of PhMgCl, MeMgBr and allylMgBr to chiral imides 1 has been studied under various conditions. The presence of a Lewis acid, as AlMe2Cl, affords an enhanced diastereoselectivity favouring the formation of the product derived from the attack on the re face. The 1,4 addition of allyl diisopropoxyborate to imides 1 has also been analysed.

Addition diastereoselective d'allyl cuprates a des imides chirales insaturees

Magnesium diallyl cuprate will add to unsaturated imides, synthesized from chiral imidazolidinones, with very high diastereoselectivity and good yields.Isoprenyl cuprate gives addition with lower yield and stereoselectivity.The products show total allylic inversion.