128899-99-0Relevant articles and documents
The direct synthesis of unsymmetrical vicinal diamines from terminal alkynes: A tandem sequential approach for the synthesis of imidazolidinones
Lee, Alison V.,Sajitz, Melanie,Schafer, Laurel L.
experimental part, p. 97 - 104 (2009/07/18)
The combination of titanium-catalyzed anti-Markovni- kov hydroamination of terminal alkynes with the Strecker reaction is used in the synthesis of unsymmetrical vicinal diamines via the one-pot synthesis of α-cyanoamines. This methodology is further applied to the efficient synthesis of imidazolidinones. An easy-to-use bis(amidate)titanium precatalyst permits efficient approaches to heterocyclic chemistry from terminal alkynes. Georg Thieme Verlag Stuttgart.
Synthesis and antitumor activity of platinum(II) complexes containing substituted ethylenediamine ligands
Brunner, Henri,Hankofer, Peter,Holzinger, Ulrich,Treittinger, Barbara,Schoenenberger, Helmut
, p. 35 - 44 (2007/10/02)
The synthesis of substituted ethylenediamines, their reactions with K2PtCl4 to give the dichloroplatinum(II) complexes, and the exchange of the chloro ligands for other leaving groups are described.The new compounds have been tested as antitumor agents both in vitro using the hormone independent human mammary carcinoma cell line MDA-MB 231 as well as in vivo using the lymphocytic P388 leukemia of the CD2F1-mouse.In the P388 test, 53 of the 55 tested complexes fulfill the minimum activity of 125percent T/C required for a substance to be active.
Tumor retarding (1-benzyl-ethylenediamine)-platin (II)-complexes
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, (2008/06/13)
There are described (1-benzylethylenediamine)-platin(II)-complexes of the general formula: STR1 wherein the radicals R1, R2, R3, and R4 are the same or different and are hydrogen, a C1 -C6