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1289038-89-6

3-Hydroxy-5-Methoxypyridine-4-carbaldehyde is a chemical compound with the molecular formula C8H7NO3. It is a derivative of pyridine and contains a hydroxyl group and a methoxy group. 3-Hydroxy-5-Methoxypyridine-4-carbaldehyde is known for its potential biological activities and pharmacological properties, making it a valuable intermediate in the synthesis of various organic compounds.
Used in Pharmaceutical Industry:
3-Hydroxy-5-Methoxypyridine-4-carbaldehyde is used as an intermediate in the synthesis of pharmaceuticals for its potential applications in medicinal chemistry and drug discovery. Its unique structure and functional groups contribute to the development of new drugs with therapeutic benefits.
Used in Agrochemical Industry:
3-Hydroxy-5-Methoxypyridine-4-carbaldehyde is also used as an intermediate in the synthesis of agrochemicals, where it can contribute to the development of new pesticides, herbicides, or other agricultural products that can improve crop yield and protect against pests.
Used in Antioxidant Research:
3-Hydroxy-5-Methoxypyridine-4-carbaldehyde is used as a subject of research for its potential antioxidant properties. Its ability to combat oxidative stress and protect cells from damage makes it a promising candidate for further studies in the development of antioxidant therapies.
Used in Anti-Inflammatory Research:
3-Hydroxy-5-Methoxypyridine-4-carbaldehyde is used as a subject of research for its potential anti-inflammatory properties. Its capacity to reduce inflammation and alleviate symptoms associated with inflammatory conditions positions it as a candidate for the development of new anti-inflammatory drugs.

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  • 1289038-89-6 Structure

  • Basic information

    1. Product Name: 3-Hydroxy-5-Methoxypyridine-4-carbaldehyde
    2. Synonyms: 3-Hydroxy-5-Methoxypyridine-4-carbaldehyde;3-Hydroxy-5-Methoxyisonicotinaldehyde
    3. CAS NO:1289038-89-6
    4. Molecular Formula: C7H7NO3
    5. Molecular Weight: 153.13538
    6. EINECS: -0
    7. Product Categories: N/A
    8. Mol File: 1289038-89-6.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 3-Hydroxy-5-Methoxypyridine-4-carbaldehyde(CAS DataBase Reference)
    10. NIST Chemistry Reference: 3-Hydroxy-5-Methoxypyridine-4-carbaldehyde(1289038-89-6)
    11. EPA Substance Registry System: 3-Hydroxy-5-Methoxypyridine-4-carbaldehyde(1289038-89-6)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1289038-89-6(Hazardous Substances Data)

1289038-89-6 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1289038-89-6 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,8,9,0,3 and 8 respectively; the second part has 2 digits, 8 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 1289038-89:
(9*1)+(8*2)+(7*8)+(6*9)+(5*0)+(4*3)+(3*8)+(2*8)+(1*9)=196
196 % 10 = 6
So 1289038-89-6 is a valid CAS Registry Number.

1289038-89-6Downstream Products

1289038-89-6Relevant articles and documents

Discovery of GBT440, an Orally Bioavailable R-State Stabilizer of Sickle Cell Hemoglobin

Metcalf, Brian,Chuang, Chihyuan,Dufu, Kobina,Patel, Mira P.,Silva-Garcia, Abel,Johnson, Carl,Lu, Qing,Partridge, James R.,Patskovska, Larysa,Patskovsky, Yury,Almo, Steven C.,Jacobson, Matthew P.,Hua, Lan,Xu, Qing,Gwaltney, Stephen L.,Yee, Calvin,Harris, Jason,Morgan, Bradley P.,James, Joyce,Xu, Donghong,Hutchaleelaha, Athiwat,Paulvannan, Kumar,Oksenberg, Donna,Li, Zhe

supporting information, p. 321 - 326 (2017/03/17)

We report the discovery of a new potent allosteric effector of sickle cell hemoglobin, GBT440 (36), that increases the affinity of hemoglobin for oxygen and consequently inhibits its polymerization when subjected to hypoxic conditions. Unlike earlier allosteric activators that bind covalently to hemoglobin in a 2:1 stoichiometry, 36 binds with a 1:1 stoichiometry. Compound 36 is orally bioavailable and partitions highly and favorably into the red blood cell with a RBC/plasma ratio of ～150. This partitioning onto the target protein is anticipated to allow therapeutic concentrations to be achieved in the red blood cell at low plasma concentrations. GBT440 (36) is in Phase 3 clinical trials for the treatment of sickle cell disease (NCT03036813).

SUBSTITUTED HETEROARYL ALDEHYDE COMPOUNDS AND METHODS FOR THEIR USE IN INCREASING TISSUE OXYGENATION

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Paragraph 0586; 0587, (2015/12/25)

Provided are substituted heteroaryl aldehydes and derivatives thereof that act as allosteric modulators of hemoglobin, methods and intermediates for their preparation, pharmaceutical compositions comprising the modulators, and methods for their use in treating disorders mediate by hemoglobin and disorders that would benefit from increased tissue oxygenation.

INHIBITORS OF THE KYNURENINE PATHWAY

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, (2014/12/12)

The present application provides novel inhibitors of indoleamine 2,3-dioxygenase-1 and/or indoleamine 2,3-dioxygenase-2 and/or tryptophan 2,3-dioxygenase, metabolites thereof, and phannaceutically acceptable salts or prodrugs thereof. Also provided are methods for preparing these compounds. A therapeutically effective amount of one or more of the compounds of formula (I) is useful in treating diseases resulting from dysregulation of the kynurenine pathway. Compounds of formula (I) act by inhibiting the enzymatic activity or expression of indoleamine 2,3-dioxygenase-1 and/or indoleamine 2,3-dioxygenase-2 and/or tryptophan 2,3-dioxygenase.

SUBSTITUTED HETEROARYL ALDEHYDE COMPOUNDS AND METHODS FOR THEIR USE IN INCREASING TISSUE OXYGENATION

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Paragraph 0317, (2013/07/19)

Provided are substituted heteroaryl aldehydes and derivatives thereof that act as allosteric modulators of hemoglobin, methods and intermediates for their preparation, pharmaceutical compositions comprising the modulators, and methods for their use in treating disorders mediate by hemoglobin and disorders that would benefit from increased tissue oxygenation.

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