204862-70-4

Basic information

• Product Name: 3,5-DIMETHOXYPYRIDINE-4-CARBOXALDEHYDE
• Synonyms: 3,5-DIMETHOXYPYRIDINE-4-CARBOXALDEHYDE;3,5-Dimethoxy-4-pyridinecarboxaldehyde;3,5-Dimethoxyisonicotinaldehyde;2-forMyl-3,5-diMethoxypyridine-4-carboxylic acid
• CAS NO: 204862-70-4
• Molecular Formula: C₈H₉NO₃
• Molecular Weight: 167.16
• EINECS: 201-215-5
• Product Categories: Pyridines
• Mol File: 204862-70-4.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 319.6ºC at 760 mmHg
• Flash Point: 147.1ºC
• Appearance: /
• Density: 1.174
• Vapor Pressure: 0.000335mmHg at 25°C
• Refractive Index: 1.537
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 3,5-DIMETHOXYPYRIDINE-4-CARBOXALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-DIMETHOXYPYRIDINE-4-CARBOXALDEHYDE(204862-70-4)
• EPA Substance Registry System: 3,5-DIMETHOXYPYRIDINE-4-CARBOXALDEHYDE(204862-70-4)

Safety Data

• Hazardous Substances Data: 204862-70-4(Hazardous Substances Data)

Usage

General Description

3,5-Dimethoxypyridine-4-carboxaldehyde is a chemical compound with the molecular formula C9H9NO3. It is a yellow liquid that is commonly used as an intermediate in the synthesis of pharmaceutical and agricultural products. 3,5-DIMETHOXYPYRIDINE-4-CARBOXALDEHYDE is known for its aromatic and aldehyde functional groups, making it a valuable building block in organic synthesis. It is also used in the production of dyes and pigments, as well as in the manufacture of flavor and fragrance compounds. 3,5-Dimethoxypyridine-4-carboxaldehyde is considered to be a versatile and important chemical in the field of organic chemistry.

InChI:InChI=1/C8H9NO3/c1-11-7-3-9-4-8(12-2)6(7)5-10/h3-5H,1-2H3

Upstream product

• 71902-33-5 3,5-difluoropyridine 
• 18677-48-0 3,5-dimethoxypyridine 
• 68-12-2 N,N-dimethyl-formamide 

Downstream Products

• 1289038-89-6 3-hydroxy-5-methoxypyridin-4-carbaldehyde 
• 1062205-27-9 3-(9-{1-[(2,6-dimethoxypyridin-4-yl)methyl]piperidin-4-yl}-6-morpholin-4-yl-9H-purin-2-yl)phenol 
• 1062205-00-8 [3-(9-{1-[(2,6-dimethoxypyridin-3-yl)methyl]piperidin-4-yl}-6-morpholin-4-yl-9H-purin-2-yl)phenyl]methanol 

Relevant articles and documents

Discovery of GBT440, an Orally Bioavailable R-State Stabilizer of Sickle Cell Hemoglobin

We report the discovery of a new potent allosteric effector of sickle cell hemoglobin, GBT440 (36), that increases the affinity of hemoglobin for oxygen and consequently inhibits its polymerization when subjected to hypoxic conditions. Unlike earlier allosteric activators that bind covalently to hemoglobin in a 2:1 stoichiometry, 36 binds with a 1:1 stoichiometry. Compound 36 is orally bioavailable and partitions highly and favorably into the red blood cell with a RBC/plasma ratio of ～150. This partitioning onto the target protein is anticipated to allow therapeutic concentrations to be achieved in the red blood cell at low plasma concentrations. GBT440 (36) is in Phase 3 clinical trials for the treatment of sickle cell disease (NCT03036813).

SUBSTITUTED HETEROARYL ALDEHYDE COMPOUNDS AND METHODS FOR THEIR USE IN INCREASING TISSUE OXYGENATION

Provided are substituted heteroaryl aldehydes and derivatives thereof that act as allosteric modulators of hemoglobin, methods and intermediates for their preparation, pharmaceutical compositions comprising the modulators, and methods for their use in treating disorders mediate by hemoglobin and disorders that would benefit from increased tissue oxygenation.

SUBSTITUTED VINYL PYRIDINE DERIVATIVE AND DRUGS CONTAINING THE SAME

The present invention relates to a substituted vinylpyridine derivative represented by the following formula (1): (wherein R1 represents a hydrogen atom, an alkyl group, etc., R2 represents an alkyl group; one of R3 and R4, which are different from each o