1289116-85-3Relevant articles and documents
Synthesis and biological evaluation of 1,4-benzodiazepin-2-ones with antitrypanosomal activity
Spencer, John,Rathnam, Rajendra P.,Harvey, Alan L.,Clements, Carol J.,Clark, Rachel L.,Barrett, Michael P.,Wong, Pui Ee,Male, Louise,Coles, Simon J.,MacKay, Simon P.
, p. 1802 - 1815 (2011/04/17)
A library of 1,4-benzodiazepines has been synthesized and evaluated against Trypanosoma brucei, a causative parasite of Human African trypanosomiasis. Benzodiazepines possessing a P2- transporter motif were found to have MIC values as low as 0.78 μM.