1289116-77-3

Basic information

• Product Name: (S)-3-benzyl-1-(2-nitrobenzyl)-5-phenyl-1H-benzo[e][1,4]-diazepin-2(3H)-one
• Synonyms: (S)-3-benzyl-1-(2-nitrobenzyl)-5-phenyl-1H-benzo[e][1,4]-diazepin-2(3H)-one
• CAS NO: 1289116-77-3
• Molecular Weight: 461.52
• Mol File: 1289116-77-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (S)-3-benzyl-1-(2-nitrobenzyl)-5-phenyl-1H-benzo[e][1,4]-diazepin-2(3H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-3-benzyl-1-(2-nitrobenzyl)-5-phenyl-1H-benzo[e][1,4]-diazepin-2(3H)-one(1289116-77-3)
• EPA Substance Registry System: (S)-3-benzyl-1-(2-nitrobenzyl)-5-phenyl-1H-benzo[e][1,4]-diazepin-2(3H)-one(1289116-77-3)

Safety Data

• Hazardous Substances Data: 1289116-77-3(Hazardous Substances Data)

Upstream product

• 2835-77-0 (2-aminophenyl)(phenyl)methanone 
• 3958-60-9 2-nitrophenylmethyl bromide 
• 884492-66-4 (S)-3-benzyl-5-phenyl-1,3-dihydro-2H-benzo[e][1,4]diazepin-2-one 

Downstream Products

• 1289116-85-3 (S)-1-(2-aminobenzyl)-3-benzyl-5-phenyl-1H-benzo[e]-[1,4]diazepin-2(3H)-one 

Relevant articles and documents

Synthesis and biological evaluation of 1,4-benzodiazepin-2-ones with antitrypanosomal activity

A library of 1,4-benzodiazepines has been synthesized and evaluated against Trypanosoma brucei, a causative parasite of Human African trypanosomiasis. Benzodiazepines possessing a P2- transporter motif were found to have MIC values as low as 0.78 μM.