1289129-58-3Relevant academic research and scientific papers
One-pot synthesis of chiral α-substituted β,γ-epoxy aldehyde derivatives through an asymmetric aldol reaction of chloroacetaldehyde
Hayashi, Yujiro,Yasui, Yusuke,Kawamura, Tsuyoshi,Kojima, Masahiro,Ishikawa, Hayato
, p. 2804 - 2807 (2011)
Water is welcome! Chiral α-substituted β,γ-epoxides have been prepared in good yields and with excellent enantioselectivities in a one-pot synthetic procedure. The key reaction of this process, which involves a series of uninterrupted sequential reactions, is an asymmetric aldol reaction of aqueous chloroacetaldehyde mediated by a diarylprolinol derivative (see scheme). Copyright
