1289139-26-9Relevant articles and documents
Pyrazolo[4,3- d ]pyrimidine bioisostere of roscovitine: Evaluation of a novel selective inhibitor of cyclin-dependent kinases with antiproliferative activity
Jorda, Radek,Havlí?ek, Libor,McNae, Iain W.,Walkinshaw, Malcolm D.,Voller, Ji?í,?turc, Antonín,Navrátilová, Jana,Kuzma, Marek,Mistrík, Martin,Bártek, Ji?í,Strnad, Miroslav,Kry?tof, Vladimír
experimental part, p. 2980 - 2993 (2011/06/21)
Inhibition of cyclin-dependent kinases (CDKs) with small molecules has been suggested as a strategy for treatment of cancer, based on deregulation of CDKs commonly found in many types of human tumors. Here, a new potent CDK2 inhibitor with pyrazolo[4,3-d]