1289141-75-8 Usage
Contains a phenol group
A hydroxyl group (-OH) bonded to a benzene ring.
Contains a pyrimidine ring
A six-membered nitrogen-containing aromatic heterocyclic ring.
Has an amino group
A nitrogen atom bonded to two hydrogen atoms (-NH2).
Synthetic organic compound
A chemical that is man-made and not found naturally in the environment.
Potential biological activities
The chemical may have effects on living organisms due to the presence of the indole and pyrimidine moieties.
Commonly found in pharmaceuticals and biologically active compounds
Indole and pyrimidine are often found in drugs and other compounds that have an effect on biological systems.
Structural features
The chemical has a specific arrangement of atoms and functional groups that may allow it to interact with biological targets.
Further studies and research needed
More research is required to fully understand the properties and potential uses of this chemical.
Check Digit Verification of cas no
The CAS Registry Mumber 1289141-75-8 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,8,9,1,4 and 1 respectively; the second part has 2 digits, 7 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1289141-75:
(9*1)+(8*2)+(7*8)+(6*9)+(5*1)+(4*4)+(3*1)+(2*7)+(1*5)=178
178 % 10 = 8
So 1289141-75-8 is a valid CAS Registry Number.
1289141-75-8Relevant articles and documents
Synthesis and biological evaluation of 2,4,5-substituted pyrimidines as a new class of tubulin polymerization inhibitors
Xie, Fuchun,Zhao, Hongbing,Li, Dewen,Chen, Hong,Quan, Haitian,Shi, Xiaojing,Lou, Liguang,Hu, Youhong
, p. 3200 - 3205 (2011/07/09)
Figure Presented. Members of a series of 2,4,5-substituted pyrimidine derivatives were synthesized, and their interactions with tubulin and their antiproliferative activities against the human hepatocellular carcinoma cells of liver (BEL-7402) were evaluated. One member of this family, the indole-pyrimidine 4k, having an indole-aryl-substituted aminopyrimidine structure, was observed to be an excellent inhibitor of tubulin polymerization (IC50 = 0.79 μM) and to display significantly high antiproliferative activities against several cancer cell lines with IC 50 values ranging from 16 to 62 nM. This substance displayed a high propensity to arrests cells at the G2/M phase of the cell cycle (EC50 = 20 nM). In addition, 4k was found to competitively inhibit colchicine binding to tubulin, indicating that it binds to the colchicine-binding site of tubulin. The observations made in this investigation demonstrate that 2,4,5-substituted pyrimidines represent a new class of tubulin polymerization inhibitors with significant antiproliferative activity.
