1289141-77-0

Basic information

• Product Name: 2-(2-aMino-5-(1-Methyl-1H-indol-5-yl)pyriMidin-4-yl)phenol
• Synonyms: 2-(2-aMino-5-(1-Methyl-1H-indol-5-yl)pyriMidin-4-yl)phenol
• CAS NO: 1289141-77-0
• Molecular Formula: C₁₉H₁₆N₄O
• Molecular Weight: 316.35654
• Mol File: 1289141-77-0.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(2-aMino-5-(1-Methyl-1H-indol-5-yl)pyriMidin-4-yl)phenol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-aMino-5-(1-Methyl-1H-indol-5-yl)pyriMidin-4-yl)phenol(1289141-77-0)
• EPA Substance Registry System: 2-(2-aMino-5-(1-Methyl-1H-indol-5-yl)pyriMidin-4-yl)phenol(1289141-77-0)

Safety Data

• Hazardous Substances Data: 1289141-77-0(Hazardous Substances Data)

Usage

Chemical Class

The compound belongs to the class of organic compounds known as phenol derivatives.

Structure

It is a heterocyclic aromatic amine that contains a pyrimidine ring fused to a phenol moiety.

Medical Applications

The compound has potential medical applications as a potent inhibitor of tyrosine kinases, making it a promising candidate for the treatment of various types of cancer.

Anti-Inflammatory and Analgesic Effects

The compound has been studied for its potential anti-inflammatory and analgesic effects.

Indole Group

The presence of the indole group may contribute to its biological activities, as indole derivatives have been known to exhibit diverse pharmacological properties.

Further Research

More research is needed to fully understand the therapeutic potential and biological activities of this compound.

Upstream product

• 192182-55-1 (1-methyl-1H-indol-5-yl)boronic acid 
• 10075-52-2 5-bromo-1-methyl-H-indole 

Relevant articles and documents

Synthesis and biological evaluation of 2,4,5-substituted pyrimidines as a new class of tubulin polymerization inhibitors

Figure Presented. Members of a series of 2,4,5-substituted pyrimidine derivatives were synthesized, and their interactions with tubulin and their antiproliferative activities against the human hepatocellular carcinoma cells of liver (BEL-7402) were evaluated. One member of this family, the indole-pyrimidine 4k, having an indole-aryl-substituted aminopyrimidine structure, was observed to be an excellent inhibitor of tubulin polymerization (IC50 = 0.79 μM) and to display significantly high antiproliferative activities against several cancer cell lines with IC 50 values ranging from 16 to 62 nM. This substance displayed a high propensity to arrests cells at the G2/M phase of the cell cycle (EC50 = 20 nM). In addition, 4k was found to competitively inhibit colchicine binding to tubulin, indicating that it binds to the colchicine-binding site of tubulin. The observations made in this investigation demonstrate that 2,4,5-substituted pyrimidines represent a new class of tubulin polymerization inhibitors with significant antiproliferative activity.