192182-55-1

Usage

Uses

Used in Pharmaceutical Industry:
1-METHYL-1H-INDOLE-5-BORONIC ACID 2,2-DIMETHYL PROPANE DIOL-1,3-CYCLIC ESTER is used as a reagent in organic synthesis for the development of new pharmaceutical compounds. Its boronic acid component is particularly valuable in the Suzuki-Miyaura coupling reaction, which is a key process in the synthesis of various bioactive molecules and pharmaceutical agents.
Used in Materials Science:
In the field of materials science, 1-METHYL-1H-INDOLE-5-BORONIC ACID 2,2-DIMETHYL PROPANE DIOL-1,3-CYCLIC ESTER is used as a monomer in the production of high-performance polymer materials. Its cyclic ester component contributes to the creation of adhesives and coatings with superior adhesion and UV resistance, making it suitable for applications requiring durability and stability under various environmental conditions.
Used in Organic Synthesis:
1-METHYL-1H-INDOLE-5-BORONIC ACID 2,2-DIMETHYL PROPANE DIOL-1,3-CYCLIC ESTER is utilized as an intermediate in organic synthesis for the preparation of complex organic molecules. Its unique structure allows for further chemical modifications and functionalization, expanding the scope of synthetic chemistry and enabling the development of novel compounds with potential applications in various industries.

InChI:InChI=1/C9H10BNO2/c1-11-5-4-7-6-8(10(12)13)2-3-9(7)11/h2-6,12-13H,1H3

Upstream product

• 10075-52-2 5-bromo-1-methyl-H-indole 
• 10075-50-0 5-bromo-1H-indole 
• 837392-62-8 1-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole 

Downstream Products

• 1242733-93-2 potassium trifluoro(1-methyl-1H-indol-5-yl)boranuide 
• 1607470-26-7 1-methyl-5-(2-nitrophenyl)-1H-indole 
• 837392-62-8 1-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole 
• 1383544-24-8 C₂₅H₂₈N₄O₃S 
• 91634-11-6 N-methyl-5-cyanoindole 
• 1426442-43-4 C₃₀H₂₅NO₂ 
• 1426442-42-3 C₂₆H₂₁NO 
• 1426442-41-2 C₂₈H₂₃N 
• 1426442-37-6 C₂₆H₂₁N 
• 1426442-36-5 C₂₆H₂₁N 
• 916518-57-5 5-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)-1-methyl-1H-indole 
• 1567837-91-5 2,4-difluoro-N-(5-(5-(1-methyl-1H-indol-5-yl)thiophen-2-yl)pyridin-3-yl)benzenesulfonamide 
• 1264670-41-8 1-methyl-5-(trifluoromethyl)-1H-indole 

Relevant academic research and scientific papers

Preparation method of benzoheterocyclic boric acid

The invention provides a preparation method of benzoheterocyclic boric acid. The preparation method comprises steps as follows: (1) a benzoheterocyclic compound shown in a formula I is dissolved in asolvent A, a liquor A is obtained, a boronylation reagent is dissolved in a solvent B, a liquor B is obtained, a palladium catalyst and an alkaline reagent are immobilized on a channel of a continuousflow reactor, the liquor A and the liquor B are subjected to a continuous adding reaction, the reaction is stopped after the mixture flows out of a reaction tube, and an intermediate is obtained; (2)the intermediate obtained in step (1) is subjected to a hydrolysis reaction, and benzoheterocyclic boric acid is obtained. According to the provided preparation method, the benzoheterocyclic boric acid is synthesized with a flow chemical technology. Compared with methods in the prior art, the method has the advantages that the product yield is 86% or above, the highest yield can reach 90% or above, the yield is very high, the reaction rate is high, energy consumption of a reaction is reduced greatly, and the method is high in operability, high in automation degree and favorable for productionoperation and industrial production.

SPIRO-SUBSTITUTED OXINDOLE DERIVATIVES HAVING AMPK ACTIVITY

The present invention relates to compounds of formula (I), which have valuable pharmacological properties, in particular are activators of AMPK and which are therefore useful in the treatment of certain disorders that can be prevented or treated by activation of this receptor. The compounds are suitable for treatment and prevention of diseases which can be influenced by this receptor, such as metabolic diseases, in particular diabetes type 2.

Synthesis and biological evaluation of 2,4,5-substituted pyrimidines as a new class of tubulin polymerization inhibitors

Figure Presented. Members of a series of 2,4,5-substituted pyrimidine derivatives were synthesized, and their interactions with tubulin and their antiproliferative activities against the human hepatocellular carcinoma cells of liver (BEL-7402) were evaluated. One member of this family, the indole-pyrimidine 4k, having an indole-aryl-substituted aminopyrimidine structure, was observed to be an excellent inhibitor of tubulin polymerization (IC50 = 0.79 μM) and to display significantly high antiproliferative activities against several cancer cell lines with IC 50 values ranging from 16 to 62 nM. This substance displayed a high propensity to arrests cells at the G2/M phase of the cell cycle (EC50 = 20 nM). In addition, 4k was found to competitively inhibit colchicine binding to tubulin, indicating that it binds to the colchicine-binding site of tubulin. The observations made in this investigation demonstrate that 2,4,5-substituted pyrimidines represent a new class of tubulin polymerization inhibitors with significant antiproliferative activity.