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192182-55-1

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192182-55-1 Usage

General Description

1-Methyl-1H-indole-5-boronic acid and 2,2-dimethyl propane diol-1,3-cyclic ester are both organic chemicals. 1-Methyl-1H-indole-5-boronic acid is a boronic acid derivative used in organic synthesis and medicinal chemistry. It is commonly used as a reagent in the Suzuki-Miyaura coupling reaction to form carbon-carbon bonds. 2,2-dimethyl propane diol-1,3-cyclic ester, also known as Isobornyl acrylate, is a cyclic ester compound used in the manufacture of adhesives, coatings, and other polymer materials. It is a versatile monomer with excellent adhesion properties and good UV resistance. Both chemicals have important applications in the fields of pharmaceuticals, organic synthesis, and materials science.

Check Digit Verification of cas no

The CAS Registry Mumber 192182-55-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,9,2,1,8 and 2 respectively; the second part has 2 digits, 5 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 192182-55:
(8*1)+(7*9)+(6*2)+(5*1)+(4*8)+(3*2)+(2*5)+(1*5)=141
141 % 10 = 1
So 192182-55-1 is a valid CAS Registry Number.
InChI:InChI=1/C9H10BNO2/c1-11-5-4-7-6-8(10(12)13)2-3-9(7)11/h2-6,12-13H,1H3

192182-55-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-Methylindole-5-boronic acid

1.2 Other means of identification

Product number -
Other names (1-methylindol-5-yl)boronic acid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:192182-55-1 SDS

192182-55-1Relevant articles and documents

Preparation method of benzoheterocyclic boric acid

-

Paragraph 0056; 0058; 0060, (2018/09/13)

The invention provides a preparation method of benzoheterocyclic boric acid. The preparation method comprises steps as follows: (1) a benzoheterocyclic compound shown in a formula I is dissolved in asolvent A, a liquor A is obtained, a boronylation reagent is dissolved in a solvent B, a liquor B is obtained, a palladium catalyst and an alkaline reagent are immobilized on a channel of a continuousflow reactor, the liquor A and the liquor B are subjected to a continuous adding reaction, the reaction is stopped after the mixture flows out of a reaction tube, and an intermediate is obtained; (2)the intermediate obtained in step (1) is subjected to a hydrolysis reaction, and benzoheterocyclic boric acid is obtained. According to the provided preparation method, the benzoheterocyclic boric acid is synthesized with a flow chemical technology. Compared with methods in the prior art, the method has the advantages that the product yield is 86% or above, the highest yield can reach 90% or above, the yield is very high, the reaction rate is high, energy consumption of a reaction is reduced greatly, and the method is high in operability, high in automation degree and favorable for productionoperation and industrial production.

Synthesis and biological evaluation of 2,4,5-substituted pyrimidines as a new class of tubulin polymerization inhibitors

Xie, Fuchun,Zhao, Hongbing,Li, Dewen,Chen, Hong,Quan, Haitian,Shi, Xiaojing,Lou, Liguang,Hu, Youhong

supporting information; experimental part, p. 3200 - 3205 (2011/07/09)

Figure Presented. Members of a series of 2,4,5-substituted pyrimidine derivatives were synthesized, and their interactions with tubulin and their antiproliferative activities against the human hepatocellular carcinoma cells of liver (BEL-7402) were evaluated. One member of this family, the indole-pyrimidine 4k, having an indole-aryl-substituted aminopyrimidine structure, was observed to be an excellent inhibitor of tubulin polymerization (IC50 = 0.79 μM) and to display significantly high antiproliferative activities against several cancer cell lines with IC 50 values ranging from 16 to 62 nM. This substance displayed a high propensity to arrests cells at the G2/M phase of the cell cycle (EC50 = 20 nM). In addition, 4k was found to competitively inhibit colchicine binding to tubulin, indicating that it binds to the colchicine-binding site of tubulin. The observations made in this investigation demonstrate that 2,4,5-substituted pyrimidines represent a new class of tubulin polymerization inhibitors with significant antiproliferative activity.

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