128915-32-2

Upstream product

• 128915-06-0 N¹⁶-(3,5-dichlorobenzoyl)-N¹,N²-di(p-nitrophenyl)formamidine 
• 622-57-1 N-ethyl-p-tolylamine 
• 2905-62-6 3,5-dichlorobenzoyl chloride 
• 100-01-6 4-nitro-aniline 
• 51-36-5 3,5-dichlorobenzoic acid 
• 6575-00-4 3,5-dichlorobenzonitrile 
• 2232-13-5 N¹,N²-di(p-nitrophenyl)formamidine 

Relevant academic research and scientific papers

Synthesis of Dichlorobenzamide Derivatives: Crystal Structures of 3,5-Dichloro-N-(2-chlorophenyl)benzamide and 3,5-Dichloro-N-(4-chlorophenyl)benzamide

Abstract: Reactions of 3,5-dichlorobenzoyl chloride and arylamine compounds in N,N′-dimethylformamidesolution at 60 °C afforded a series of dichlorobenzamidederivatives 4–14 in good yields. These new compounds and accompanyingintermediates were characterized and confirmed by nuclear magneticresonance and infrared spectroscopy, of which structures of compounds 4and 6 were established by X-ray crystallography. Compound 4 crystallizesin triclinic space group Pī, with a = 5.047 (18), b = 10.28 (4), c = 13.36 (5) ?, α =107.59 (5)°, β = 93.55 (5)°, γ = 98.34 (5)°, and Z = 2. The unit cell of 6 has a monoclinic Pn symmetry with the cell parameters a = 9.581 (3), b = 12.217 (4), c = 11.072 (3) ?, β = 92.584 (4)°, and Z = 4. Graphic Abstract: A series of 3,5-dichlorobenzamide compounds were synthesized from reactions of arylamine compounds with 3,5-dichlorobenzoyl chloride, which was prepared from 3,5-dichlorobenzonitrile.[Figure not available: see fulltext.]

Diarylureas and Diarylamides with Oxazolo[5,4-d]pyrimidine Scaffold as Angiogenesis Inhibitors

A series of oxazolopyrimidine-based ureas and amides were designed, synthesized, and biologically evaluated for their antiproliferative and antiangiogenic activities. These compounds were identified to exhibit inhibitory activities against human umbilical vein endothelial cells (HUVEC) in vitro. Among these compounds, compound 22 effectively inhibited the migration and capillary-like tube formation of human umbilical vein endothelial cells. It also exhibited a concentration-dependent inhibition on capillary sprouting from the rat aorta rings. Preliminary mechanistic studies revealed that compound 22 suppressed protein kinases activation, by decreasing PI3K and ERK 1/2 phosphorylation. These results support the further investigation of this class of compounds as potential anticancer agents.