128915-50-4

Upstream product

• 123-11-5 4-methoxy-benzaldehyde 
• 126-81-8 dimedone 
• 105-45-3 acetoacetic acid methyl ester 
• 504-02-9 1,3-cylohexanedione 
• 14205-39-1 methyl (E)-3-aminocrotonate 

Relevant academic research and scientific papers

Mo@GAA-Fe3O4MNPs: a highly efficient and environmentally friendly heterogeneous magnetic nanocatalyst for the synthesis of polyhydroquinoline derivatives

Polyhydroquinolines were efficiently obtained from a sequential four-component reaction between dimedone or 1,3-cyclohexandione, ethyl acetoacetate, or methyl acetoacetate as a β-ketoester, aldehydes, and ammonium acetate, under the catalysis of Mo@GAA-Fe3O4MNPs as a green, effective, recyclable, and environmentally friendly nanocatalyst. Due to its magnetic nature the prepared catalyst can be easily separated from the reaction mixture by an external magnet and reused several times without significant changes in catalytic activity and reaction efficiency. The catalyst was characterized using energy dispersive X-ray spectroscopy (EDX), X-ray diffraction (XRD), thermogravimetric analysis (TGA), Fourier transform infrared spectroscopy (FTIR), vibrating sample magnetometry (VSM), scanning electron microscopy (SEM), and transmission electron microscopy (TEM).

A new In-SiO2 composite catalyst in the solvent-free multicomponent synthesis of Ca2+ channel blockers nifedipine and nemadipine B

An In-SiO2 composite was prepared by the sol-gel method and was applied as a heterogeneous Lewis acid catalyst in the multicomponent Hantzsch synthesis of symmetrical and non-symmetrical 1,4-DHPs. The Ca2+ channel blockers nifedipine and nemadipine B were synthesized in a single step through a solvent-free protocol. The Royal Society of Chemistry and the Centre National de la Recherche Scientifique 2012.

Combined thiourea dioxidewater: An effective reusable catalyst for the synthesis of polyhydroquinolines via hantzsch multicomponent coupling

Thiourea dioxide in water was found to be an efficient and reusable organocatalytic system for the one-pot synthesis of polyhydroquinoline derivatives via the Hantzsch-type coupling of aldehyde, dimedone, acetoacetate, and ammonium acetate under mild reaction conditions. Operational simplicity, the use of an economically affordable catalyst, environmentally benign conditions, high product yields, and reusability of the catalyst system were the advantageous features of the developed method.

P-toluene sulfonic acid catalyzed one-pot synthesis of unsymmetrical 1,4-dihydropyridines derivatives via hantzsch reaction

A simple, inexpensive and efficient one-pot synthesis of a series of unsymmetrical 1,4-dihydropyridines derivatives using p-toluene sulfonic acid as catalyst at room temperature was achieved in excellent yields from the four-component Hantzsch condensation reactions of various aromatic aldehydes, 1,3-cyclohexanedione, methyl acetoacetate (or ethyl acetoacetate) and ammonium acetate in a little methanol (or ethanol). The procedure possesses the advantages of short reaction time, high yields, an environmental friendly procedure as well as easy isolation of products.

A facile four component one-pot synthesis of polyhydroquinoline derivatives catalyzed by ionic liquid via modified Hantzsch reaction

An efficient and newer Hantzsch reaction for the synthesis of polyhydroquinoline derivatives have been reported via fourcomponent condensation of aldehydes, cyclic 1,3-diketones, β-keto esters, NH4OAc and catalytic amount of ionic liquid 1-Viny

Silica sulfuric acid: An efficient and versatile catalyst for one-pot synthesis of substituted 5-Oxo-1,4,5,6,7,8-hexahydroquinoline derivatives

An easy method for synthesis of substituted 5-oxo-1,4,5,6,7,8- hexahydroquinoline derivatives from 5,5-dimethyl-1,3-cyclohexanedione or 1,3-cyclohexanedione, arylaldehyde, methyl acetoacetate and ammonium acetate using silica sulfuric acid as catalyst is