128916-36-9Relevant academic research and scientific papers
Studies on the stereoselective methylation of α-sulfinyl carbanions generated from three isomeric pyridylmethyl π-tolyl sulfoxides and benzyl 2-pyridyl sulfoxide
Furukawa,Hosono,Fujihara,Ogawa
, p. 461 - 465 (2007/10/02)
A high stereoselectivity in the methylation of 2-pyridylmethyl p-totyl sulfoxide (2a) with lithium diisopropylamide and iodomethane was observed at low temperature. The chelation of Li+ by both the nitrogen atom in the pyridine ring and the sulfinyl oxygen atom in 2a promotes the stereoselectivity as compared with isomeric sulfoxides.
