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1289210-47-4

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1289210-47-4

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1289210-47-4 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1289210-47-4 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,8,9,2,1 and 0 respectively; the second part has 2 digits, 4 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1289210-47:
(9*1)+(8*2)+(7*8)+(6*9)+(5*2)+(4*1)+(3*0)+(2*4)+(1*7)=164
164 % 10 = 4
So 1289210-47-4 is a valid CAS Registry Number.

1289210-47-4Downstream Products

1289210-47-4Relevant articles and documents

The synthesis and SAR of novel diarylsulfone 11β-HSD1 inhibitors

Yan, Xuelei,Wang, Zhulun,Sudom, Athena,Cardozo, Mario,Degraffenreid, Michael,Di, Yongmei,Fan, Pingchen,He, Xiao,Jaen, Juan C.,Labelle, Marc,Liu, Jinsong,Ma, Ji,McMinn, Dustin,Miao, Shichang,Sun, Daqing,Tang, Liang,Tu, Hua,Ursu, Stefania,Walker, Nigel,Ye, Qiuping,Powers, Jay P.

scheme or table, p. 7071 - 7075 (2011/01/03)

In this communication, human 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitory activities of a novel series of diarylsulfones are described. Optimization of this series resulted in several highly potent 11β-HSD1 inhibitors with excellent pharmacokinetic (PK) properties. Compound (S)-25 showed excellent efficacy in a non-human primate ex vivo pharmacodynamic model.

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