1289210-83-8Relevant academic research and scientific papers
Structure-Based Discovery of Proline-Derived Arginase Inhibitors with Improved Oral Bioavailability for Immuno-Oncology
Lu, Min,Zhang, Hongjun,Li, Derun,Childers, Matthew,Pu, Qinglin,Palte, Rachel L.,Gathiaka, Symon,Lyons, Thomas W.,Palani, Anandan,Fan, Peter W.,Spacciapoli, Peter,Miller, J. Richard,Cho, Hyelim,Cheng, Mangeng,Chakravarthy, Kalyan,O'Neil, Jennifer,Eangoor, Padmanabhan,Beard, Adam,Kim, Hai-Young,Saurí, Josep,Gunaydin, Hakan,Sloman, David L.,Siliphaivanh, Phieng,Cumming, Jared,Fischer, Christian
supporting information, p. 1380 - 1388 (2021/08/06)
Recent data suggest that the inhibition of arginase (ARG) has therapeutic potential for the treatment of a number of indications ranging from pulmonary and vascular disease to cancer. Thus, high demand exists for selective small molecule ARG inhibitors wi
COMPOUNDS AND METHODS OF USE
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Paragraph 0653, (2021/05/07)
Compounds are provided according to Formula (I): and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof; wherein X1, X2, X3, X4, X5, A, L, R1, R2, R5, m and n are as defined herein. Compounds of the present invention are contemplated useful for the prevention and treatment of a variety of conditions.
Compounds and methods of use
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Page/Page column 433; 436; 459, (2021/08/04)
Compounds are provided according to Formula (I): and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof; wherein X1, X2, X3, X4, Y, A, L1, L2, R1, R2, R5, m and n are as defined herein. Compounds of the present invention are contemplated useful for the prevention and treatment of a variety of conditions.
ARGINASE INHIBITORS AND METHODS OF USE
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Page/Page column 75-76, (2019/10/04)
Described herein are compounds of Formula I or a pharmaceutically acceptable salt thereof. The compounds of Formula I act as arginase inhibitors and can be useful in preventing, treating or acting as a remedial agent for arginase-related diseases.
NOVEL FERROPORTIN INHIBITORS
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Page/Page column 334; 335, (2017/05/10)
The invention relates to novel ferroportin inhibitors of the general formula (I) pharmaceutical compositions comprising them and the use thereof as medicaments, in particular for the prophylaxis and/or treatment of diseases caused by a lack of hepcidin or iron metabolism disorders, such as particularly iron overload states such as in particular thalassemia and hemochromatosis.
PROTEIN KINASE INHIBITORS AND METHODS OF TREATMENT
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Page/Page column 94, (2012/02/01)
The present invention relates to chemical compounds of formula (I) and methods for their use and preparation. In particular, the invention relates to substituted pyrazolo[3,4-d]pyrimidine based compounds which can be used in treating proliferative disorders, use of these compounds in methods of therapy and the manufacture of medicaments as well as compositions containing these compounds.
