1289377-95-2Relevant academic research and scientific papers
Synthesis of [1,2,4]-triazolo-annulated 3-aza-A-homocholestanes - A novel class of pentacyclic compounds
Bai, Hexiang,Xia, Shijing,Li, Zhiming,Wang, Jingmei,Wang, Quanrui
experimental part, p. 521 - 527 (2012/05/05)
This study was performed to investigate the reactivity of azocarbenium salts derived from 5α-cholestan-3-one towards 1,3-dipolar cycloaddition reactions with inverse electron-demand to produce unprecedented steroidal heterocyclic derivatives, i.e. [1,2,4]
Synthesis and crystal structure of [1,2,4]-triazolo-annulated 3-aza-A-homocholestane derivative: A novel pentaheterocyclic ring system
Bai, He-Xiang,Wang, Jing-Mei,Xia, Shi-Jing,Wang, Quan-Rui
, p. 316 - 321 (2011/10/05)
A novel pentaheterocyclic ring system derived from (5α)-cholestan-3- one, i.e. [1R-[1α(R*),3aβ,3bα,5aβ,12aα, 12bβ,14aα]]-1-(1,5-dimethylhexyl)-1,2,3,3a,3b,4,5,11,12,12a,12b,13, 14,14a-tetradecahydro-8,12a,14a-trimethyl-9-(2,4,6-trichlorophenyl) -cyclopenta[5,6]naphtho[2,1-d][1,2,4]triazolo[1,5-a]azepinium hexachloroantimonate (6) has been synthesized via the reverse-electron-demand 1,3-dipolar cycloaddition of the 1-aza-2-azoniaallene cation 4 to the triple bond of acetonitrile followed by ring enlargement. The structure of 6 was determined by NMR, IR and high-resolution mass spectra, and unequivocally confirmed by X-ray crystallographic analysis. The title compound crystallizes in monoclinic class under the space group P2-1 with a = 8.163(3) A, b = 11.214(4) A, c = 24.191(9) A, α = 90°, β = 97.740(5)°, and γ = 90°. The five-membered triazole ring is essentially planar and aromatic, while the seven-membered azepine ring is not planar, but adopts a chair-like conformation.
